Jezil

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Gemfibrozil

Available from:

Pfizer Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

JEZIL™

_contains the active ingredient gemfibrozil_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Jezil.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Jezil against the
benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT JEZIL IS USED FOR
Jezil is used to help control high
levels of cholesterol and
triglycerides, which are fat-like
substances in the blood.
Jezil belongs to a group of medicines
called fibric acid derivatives or
fibrates. The exact way in which
Jezil works is not known but it is
thought to work by reducing the
"bad" (LDL) cholesterol and
triglycerides while raising the
"good" (HDL) cholesterol. This helps
keep your blood vessels unblocked
and decreases the risk of heart
disease to prevent heart attacks,
angina and stroke.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY JEZIL HAS BEEN
PRESCRIBED FOR YOU.
Your doctor may have prescribed
Jezil for another reason.
Jezil is not recommended for use in
children, as its safety and
effectiveness in children have not
been established.
Jezil is available only with a doctor's
prescription.
There is no evidence that Jezil is
addictive.
BEFORE YOU TAKE JEZIL
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE JEZIL IF YOU ARE ALLERGIC
TO:
•
medicines containing gemfibrozil
(e.g. Lopid, Gemhexal or
Lipazil),
•
any of the ingredients listed at the
end of this leaflet.
Some of the symptoms of an allergic
reaction may include
•
skin rash, itching or hives
•
swelling of the face, lips, mouth,
throat or neck
•
difficulty in swallowing or
breathing
•
wheezing or shortness of breath.
DO NOT TAKE JEZIL IF YOU HAVE:
•
severe liver disease
•
severe kidney disease
•
gallstones or gall bladder diseas

Summary of Product characteristics

Version:  pfpjezit10913 
Supersedes:  pfpjezit10310 

Page: 1 of 13 
PRODUCT INFORMATION 
JEZIL
®
 (GEMFIBROZIL) 
NAME OF MEDICINE 
JEZIL (gemfibrozil) 600 mg tablets. 
JEZIL  contains  the  active  ingredient  gemfibrozil.    Gemfibrozil  is  a  nonhalogenated 
phenoxypentanoic acid with the following structural formula: 

- O - C H 
2
 - C H 
2
 - C H 
2
 - C - C O O H 
C H 
3

C H 
3

C H 
3

C H 
3

Chemical name: 
5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid 
Molecular formula: 
C
15
H
22
0
3

Molecular weight: 
250.35 
CAS registry number: 
25812-30-0. 
DESCRIPTION 
Gemfibrozil is a white, waxy powder which is stable under ordinary conditions.  The melting 
point is 58-61

C.  Its solubility is 0.0019% (w/v) in water and in acid and over 1% in dilute 
base. 
Each  film-coated  tablet  contains  600  mg  gemfibrozil.    JEZIL  tablets  also  contain  colloidal 
anhydrous  silica,  pregelatinised  starch,  polysorbate  80,  microcystalline  cellulose, 
hypromellose,  calcium  stearate,  hydroxypropylcellulose,  methyl  hydroxybenzoate,  propyl 
hydroxybenzoate, macrogol 3500, opaspray white and
candelilla wax. 
PHARMACOLOGY 
MECHANISM OF ACTION 
Gemfibrozil’s mechanism of action has not been definitely established.  In man, Gemfibrozil 
inhibits  peripheral  lipolysis  and  decreases  the  hepatic  extraction  of  free  fatty  acids,  thus 
reducing  hepatic  triglyceride  production.    Gemfibrozil  also  inhibits  synthesis  and  increases 
clearance  of  apolipoprotein  B,  which  is  a  carrier  of  VLDL,  leading  to  a  decrease  in  VLDL 
production. 
Gemfibrozil  is  a  lipid  regulating  agent  which  decreases  serum  triglycerides  and  total 
cholesterol, and increases