IVOMEC EPRINEX (EPRINOMECTIN) POUR-ON FOR BEEF AND DAIRY CATTLE

Australia - English - APVMA (Australian Pesticides and Veterinary Medicines Authority)

Buy It Now

Active ingredient:
EPRINOMECTIN
Available from:
Boehringer Ingelheim Animal Health Australia Pty. Ltd.
INN (International Name):
eprinomectin(5mg/mL)
Pharmaceutical form:
Unknown
Composition:
EPRINOMECTIN ANTHELMINTIC Active 5.0 mg/ml
Units in package:
#(1x2.5L); #(1x20L); #22.5L; 11L; 1L; 2.5L; 20L; 250mL; 5L
Class:
VP - Veterinary Pesticide
Manufactured by:
MERIAL AUSTRALIA
Therapeutic group:
CATTLE | DEER | BEEF | BOS INDICUS | BOS TAURUS | BOVINE | BUFFALO | BULL | BULLOCK | CALF | COW | DAIRY COW | DOE | FALLOW DEER
Therapeutic area:
PARASITICIDES
Therapeutic indications:
BARBER'S POLE WORM - HAEMONCHUS PLACEI | BLACK SCOUR WORM - TRICHOSTRONGYLUS SPP. | BROWN STOMACH WORM (ADULT) - O. LYRATA | BUFFALO FLY | CATTLE BITING LOUSE | CATTLE TICK | CHORIOPTIC MANGE MITE | COOPERIA ONCOPHORA | COOPERIA PECTINATA | COOPERIA PUNCTATA | COOPERIA SURNABADA | HOOKWORM - BUNOSTOMUM PHLEBOTOMUM | INTESTINAL HAIR WORM - T. COLUBRIFORMIS | LUNGWORM - DICTYOCAULUS VIVIPARUS | MANGE MITE - S. SCABIEI VAR. BOVIS | MAZAMASTRONGYLUS SPP. - ADULT | NEMATODIRUS HELVETIANUS | NODULE WORM - OESOPHAGOSTOMUM RADIATUM | NODULE WORM - OESOPHAGOSTOMUM SPP. | OESOPHAGOSTOMUM SPP. - ADULT | OSTERTAGIA SPP. - ADULT | SHORTNOSED CATTLE LOUSE | SMALL BROWN STOMACH WORM - O. OSTERTAGI | SMALL BROWN STOMACH WORM-OSTERTAGIA SPP. | SMALL INTESTINAL WORM - COOPERIA SPP. | STOMACH HAIR WORM | SUCKING LICE - LINOGNATHUS VITULI | TRICHOSTRONGYLUS SPP. - ADULT/4TH STAGE | TUBERCLE-BEARING LOUSE | WHIPWORM (ADULT) - TRICHURIS SPP. | BLACK SCOUR WORM | CATTLEBITING LOUSE | DAMALINIA BOVIS (OLD NAME) | GASTROINTESTINAL RO
Product summary:
Poison schedule: 5; Withholding period: WHP:Cattle Milk-NIL There is no milk w ithholding period for lactating dairy c attle. Cattle Meat/Deer Meat-NIL There is no meat withholding period for slau ghter of cattle and deer. As the standa rds that are applied for eprinomectin i n overseas markets are similar to those approved in Australia, the export slau ghter interval (ESI) is the same as the withholding period i.e. EXPORT SLAUGHT ER INTERVAL: NIL.; Host/pest details: CATTLE: [BARBER'S POLE WORM - HAEMONCHUS PLACEI, BLACK SCOUR WORM - TRICHOSTRONGYLUS SPP., BROWN STOMACH WORM (ADULT) - O. LYRATA, BUFFALO FLY, CATTLE BITING LOUSE, CATTLE TICK, CHORIOPTIC MANGE MITE, COOPERIA ONCOPHORA, COOPERIA PECTINATA, COOPERIA PUNCTATA, COOPERIA SURNABADA, HOOKWORM - BUNOSTOMUM PHLEBOTOMUM, INTESTINAL HAIR WORM - T. COLUBRIFORMIS, LUNGWORM - DICTYOCAULUS VIVIPARUS, MANGE MITE - S. SCABIEI VAR. BOVIS, NEMATODIRUS HELVETIANUS, NODULE WORM - OESOPHAGOSTOMUM RADIATUM, NODULE WORM - OESOPHAGOSTOMUM SPP., SHORTNOSED CATTLE LOUSE, SMALL BROWN STOMACH WORM - O. OSTERTAGI, SMALL BROWN STOMACH WORM-OSTERTAGIA SPP., SMALL INTESTINAL WORM , STOMACH HAIR WORM, SUCKING LICE - LINOGNATHUS VITULI, TUBERCLE-BEARING LOUSE, WHIPWORM - TRICHURIS OVIS (ADULTS ONLY)]; DEER: [LUNGWORM - DICTYOCAULUS VIVIPARUS, MAZAMASTRONGYLUS SPP. - ADULT, OESOPHAGOSTOMUM SPP. - ADULT, OSTERTAGIA SPP. - ADULT, TRICHOSTRONGYLUS SPP. - ADULT/4TH STAGE]; Poison schedule: 5; Withholding period: ; Host/pest details: CATTLE: [BARBER'S POLE WORM - HAEMONCHUS PLACEI, BLACK SCOUR WORM - TRICHOSTRONGYLUS SPP., BROWN STOMACH WORM (ADULT) - O. LYRATA, BUFFALO FLY, CATTLE BITING LOUSE, CATTLE TICK, CHORIOPTIC MANGE MITE, COOPERIA ONCOPHORA, COOPERIA PECTINATA, COOPERIA PUNCTATA, COOPERIA SURNABADA, HOOKWORM - BUNOSTOMUM PHLEBOTOMUM, INTESTINAL HAIR WORM - T. COLUBRIFORMIS, LUNGWORM - DICTYOCAULUS VIVIPARUS, MANGE MITE - S. SCABIEI VAR. BOVIS, NEMATODIRUS HELVETIANUS, NODULE WORM - OESOPHAGOSTOMUM RADIATUM, NODULE WORM - OESOPHAGOSTOMUM SPP., SHORTNOSED CATTLE LOUSE, SMALL BROWN STOMACH WORM - O. OSTERTAGI, SMALL BROWN STOMACH WORM-OSTERTAGIA SPP., SMALL INTESTINAL WORM , STOMACH HAIR WORM, SUCKING LICE - LINOGNATHUS VITULI, TUBERCLE-BEARING LOUSE, WHIPWORM - TRICHURIS OVIS (ADULTS ONLY)]; DEER: [LUNGWORM - DICTYOCAULUS VIVIPARUS, MAZAMASTRONGYLUS SPP. - ADULT, OESOPHAGOSTOMUM SPP. - ADULT, OSTERTAGIA SPP. - ADULT, TRICHOSTRONGYLUS SPP. - ADULT/4TH STAGE]; For the treatment and control of internal and external parasites of beef and dairy cattle and internal parasites of deer.
Authorization status:
Registered
Authorization number:
49105
Authorization date:
2020-07-01

INDICATIONS:

For the treatment and control of gastrointestinal

roundworms

(including

inhibited

immature

Ostertagia ostertagi) and lungworm in cattle.

IVOMEC EPRINEX Pour-On for Beef and Dairy Cattle

contains eprinomectin, a member of the macrocyclic

lactone family of drenches. It is effective against

eprinomectin sensitive strains of internal parasites.

Resistance can develop to any drench.

For sucking and biting lice, sarcoptic and chorioptic

mange mites and buffalo fly in beef and dairy cattle.

IVOMEC EPRINEX Pour-On aids in control of cattle

tick (Boophilus microplus). For the treatment and

control

gastrointestinal

roundworms

lungworm in deer.

CATTLE - Gastrointestinal Roundworms:

For the control of adult and immature:

Ostertagia ostertagi (including inhibited L4) - small brown

stomach worm

O.lyrata - brown stomach worm (adults only)

Ostertagia spp.

Haemonchus placei - barbers pole worm

Trichostrongylus axei - stomach hair worm

T.colubriformis - intestinal hair worm

Trichostrongylus spp.

Cooperia spp. (including inhibited L4) - small intestinal

worm

C. oncophora

C. pectinata

C. punctata

C. surnabada

Oesophagostomum radiatum - nodule worm

Oesophagostomum spp.

Nematodirus helvetianus - thin necked intestinal worm

Bunostomum phlebotomum - hookworm

Trichuris spp. - whip worm (adults only)

Lungworm:

Adult and immature Dictyocaulus viviparus

Sucking and Biting Lice:

Linognathus vituli

Haematopinus eurysternus

Bovicola (Damalinia) bovis

Solenopotes capillatus

Mites:

Chorioptes bovis

Sarcoptes scabiei var bovis

Buffalo Fly:

Haematobia irritans exigua

When used as directed, IVOMEC EPRINEX Pour-On

for Beef and Dairy Cattle also aids in control of:

Cattle Tick:

Boophilus microplus

(Not recommended for use in strategic tick control

programs)

PERSISTENT ACTIVITY IN CATTLE:

IVOMEC

EPRINEX

Pour-On

when

given

recommended

dosage

1mL/10kg

liveweight

controls infections with:

*The following parasite species are included within

each of the relevant genera: Ostertagia ostertagi, O.

leptospicularus,

O.lyrata,

Cooperia

oncophora,

C.punctata, C. surnabada, Trichostrongylus axei, T.

colubriformis.

DEER - Gastrointestinal roundworms:

Ostertagia - type spp.*(adults)

Trichostrongylus spp. (adults and fourth stage larvae)

Mazamastrongylus spp. (adults)

Oesophagostomum spp. (adults)

*Includes

O.mossi/dikmansi,

O.lyrata,

O.leptospicularis,

Spiculopteragia

spiculoptera,

Sp.asymmetrica and Apteragia quadrispiculata.

Lungworms:

Dictyocaulus

viviparus

(adults

fourth

stage

larvae).

For best results IVOMEC EPRINEX Pour-On for Beef

and Dairy Cattle should be part of a total parasite

control

program

including

internal

external

parasites. Resistance may develop to any drench.

Consult your veterinarian for a complete parasite

control program.

DIRECTIONS FOR USE:

Dosage and administration

representative

sample

animals

should

weighed with either scales or a weighband. Dose the

mob according to the heaviest animal by liveweight in

the group (cows, bulls, calves, heifers, hinds, stags,

fawns, etc). Do not underdose. Where there is a

large variation in size within the group, draft into two

more

lines

based

bodyweight,

avoid

excessive overdosing.

This

product

formulated

only

pour-on

application to cattle and deer; do not use in other

species. The formulation should be applied along the

topline in a narrow strip extending from the withers

to the tailhead. The dose rate is 1mL for each 10kg

of liveweight.

A 20L drum contains enough solution to treat 800

head of 250kg cattle or 2000 head of 100kg dear.

Heavier animals (for example, mature bulls) should

receive an additional 5mL for each 50kg over 650kg.

Consult

your

veterinarian

assistance

diagnosis, treatment and control of parasitism.

WITHHOLDING PERIODS:

CATTLE MILK: NIL.

There is no milk withholding period for lactating

dairy cattle.

CATTLE MEAT/DEER MEAT: NIL.

There is no meat withholding period for slaughter

of cattle and deer.

As the standards that are applied for eprinomectin

in overseas markets are similar to those approved

in Australia, the export slaughter interval (ESI) is

the same as the withholding period i.e. EXPORT

SLAUGHTER INTERVAL: NIL

SAFETY:

Studies have demonstrated a wide safety margin.

Five

times

recommended

level

adverse effect on cattle or deer. Three times the

recommended use level had no adverse effect on

breeding performance of cows and bulls.

NOTE TO USER:

Rainfall before or after treatment will not affect the

efficacy of IVOMEC EPRINEX Pour-On.

PRECAUTIONS:

Close container when not in use. Do not apply to

areas of the backline covered with mud or manure.

This product is for application to skin surface only,

do not give orally or by injection.

INSTRUCTIONS FOR 20L PACK:

Replace

shipping

with

tube

assembly.

Attach the draw-off tubing to the dosing applicator

and to the top stem on the dip tube cap.

Gently prime the dosing applicator checking for

leaks.

Follow

dosing

applicator

manufacturer’s

directions for adjusting the dose and proper use

and maintenance of the equipment.

DISPOSAL:

Triple or (preferably) pressure rinse IVOMEC EPRINEX

Pour-On containers and dispose of rinsate in a disposal

pit specifically marked and set up for this purpose

clear of waterways, vegetation and roots. Return clean

container for recycling where this is an option or for

disposal at a landfill authorised to accept that waste. If

not available, bury the containers below 500 mm in the

disposal pit. Empty containers and product should not

be burnt. Very highly toxic to aquatic species. Do not

contaminate dams, rivers, streams or other waterways

with the chemical or used container.

PROTECTION OF WILDLIFE, FISH, CRUSTACEANS

AND THE ENVIRONMENT:

Studies indicate that when eprinomectin comes in

contact with the soil, it readily and tightly binds to the

soil and becomes inactive over time. Containers and

any residual contents should be disposed of safely in

approved

landfill

free

eprinomectin

adversely

affect

fish

certain

water-borne

organisms.

SAFETY DIRECTIONS:

Poisonous if swallowed. Will irritate the eyes.

Avoid contact with eyes. Repeated exposure may

cause allergic disorders. After use and before

eating, drinking or smoking, wash hands, arms and

face thoroughly with soap and water.

FIRST AID: If poisoning occurs contact a doctor or

Poisons Information Centre, phone 131126.

For further information, refer to the Material Safety

Data Sheet.

Merial Australia Pty Limited

Level 6, 79 George Street

Parramatta NSW 2150

For product information and technical enquiries visit

www.merial.au.com or call Merial Customer Solutions

Australia: 1800-808-691.

APVMA Approval No. 49105/20L/0605

Pour-On

for Beef and Dairy Cattle

®

®

(eprinomectin)

Parasite*

Ostertagia spp.

Up to 28 days

Cooperia spp.

Up to 28 days

Dictyocaulus viviparus

28 days

Nematodirus helvetianus

Up to 28 days

Prolonged Activity

Oesophagostomum radiatum

Up to 28 days

Haemonchus placei

21 days

Trichostrongylus spp.

21 days

126-150

1333

451-500

Liveweight

(kg)

Dose Volume

(ml)

Doses per Pack

Up to 50

4000

51-75

2666

76-100

2000

101-125

12.5

1600

151-175

17.5

1142

176-200

1000

201-250

251-300

301-350

351-400

401-450

501-550

551-600

601-650

Colors:

Black

Fonts:

Helvetica, and Helvetica Condensed Families

®

Pour-On for Beef and Dairy Cattle

Active Constituent: EPRINOMECTIN 5 mg/mL

CAUTION

KEEP OUT OF REACH OF CHILDREN

READ SAFETY DIRECTIONS

FOR ANIMAL TREATMENT ONLY

20 Litres

For the treatment and control of internal and external parasites of beef

and dairy cattle and internal parasites of deer.

Dose 1 mL per 10 kg liveweight. For external use only.

XXXXXXXXX

Nufarm Number

®

®

SAFETY DIRECTIONS: Poisonous if swallowed. Will irritate the eyes.

Avoid contact with eyes. Repeated exposure may cause allergic

disorders. After use and before eating, drinking or

smoking, wash hands, arms and face

thoroughly with soap and water.

FIRST AID: If poisoning occurs contact

a doctor or Poisons Information Centre,

phone 131126.

IVOMEC, EPRINEX and cattle head logo are

registered trademarks of Merial Limited.

©Merial Limited, 2005. All rights reserved.

Storage: Store below 30º C (Room

Temperature). Store bottle or pack

in carton to protect from light.

Merial Australia Pty Limited

Level 6, 79 George Street

Parramatta NSW 2150

APVMA Approval No. 49105/20L/0605

7560-2023-00

®

CAUTION

KEEP OUT OF REACH OF CHILDREN

READ SAFETY DIRECTIONS

FOR ANIMAL TREATMENT ONLY

20 Litres

Colors:

Pantone 116 C,

Pantone 289 C,

Pantone 300 C,

Pantone 874 C,

Pantone 369 C,

Black

Fonts:

Helvetica, and Helvetica Condensed Families

XXXXXXXXX

Nufarm Number

®

Pour-On for Beef and Dairy Cattle

Active Constituent: EPRINOMECTIN 5 mg/mL

®

PRINT AREA

38 x 13mm

Batch No:

Expiry Date:

For the treatment and control of internal and external parasites

of beef and dairy cattle and internal parasites of deer.

Dose 1 mL per 10 kg liveweight. For external use only.

Storage: Store below 30º C (Room Temperature).

Store bottle or pack in carton to protect from light.

Merial Australia Pty Limited

Level 6, 79 George Street

Parramatta NSW 2150

APVMA Approval No. 49105/20L/0605

SAFETY DIRECTIONS: Poisonous if swallowed. Will

irritate the eyes. Avoid contact with eyes. Repeated

exposure may cause allergic disorders. After use and

before eating, drinking or smoking, wash hands, arms

and face thoroughly with soap and water.

FIRST AID: If poisoning occurs contact a doctor

or Poisons Information Centre, phone 131126.

IVOMEC, EPRINEX and cattle head logo

are registered trademarks of Merial Limited.

©Merial Limited, 2005. All rights reserved.

7560-2023-00

3mm radius corners

140mm wide

168mm deep

15mm glue area

125mm wide

125mm wide

125mm wide

168mm deep

Square corners

Die Specification Number

Pack Size:

Date:

Merial DW170x160mm

20L Top label

11/03/05

Die Specification Number

Pack Size:

Date:

Merial DW168x140mm

20L Base label

11/03/05

Die Specification Number

Pack Size:

Date:

Merial DW168x125mm (each page)

20L Book

11/03/05

3mm radius corners

Pharmacode area

160mm wide

170mm deep

Info

pest

Verified

SECTION 1

IDENTIFICATION OF THE MATERIAL AND SUPPLIER

Other names:

Recommended use:

IVOMEC

EPRINEX

(eprinomectin) Pour-On is indicated for the treatment

and control of gastrointestinal roundworms (including inhibited immature Ostertagia ostertagi), lungworm,

grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, buffalo flies in beef and dairy cattle of all

ages, including lactating dairy cattle and for the treatment and control of gastrointestinal roundworms and

lungworm in deer.

Supplier name:

Merial Australia Pty Ltd

Address:

Level 6, 79 George Street

Parramatta NSW 2150

Telephone number (toll-free):

1800 808 691

All hours emergency phone number - Poisons Information Centre 131126, anywhere in Australia

SECTION 2

HAZARDS IDENTIFICATION

Not classified as hazardous according to criteria of NOHSC.

Not classified as Dangerous Goods according to the ADG Code.

Risk phrase(s) (Hazard):

VERY TOXIC TO AQUATIC ORGANISMS (R50)

Safety phrase(s)):

(Precautionary statements)

DO NOT EMPTY INTO DRAINS (S29)

APPROVED CRITERIA:

NOHSC CLASSIFICATION:

Not classified

SUSDP CLASSIFICATION :

POISONS SCHEDULE: 5

ADG CODE CLASSIFICATION: Not Dangerous Goods

UN No.: none

LOCAL EFFECT OF

PRODUCT:

TARGET ORGANS:

See note to physician below.

INHALATION:

As the pour-on is a liquid, this is not a likely route of entry. Unlikely to be

harmful at the low concentration of active ingredient in this product.

SKIN CONTACT:

Not irritating

EYE CONTACT:

Not irritating.

INGESTION:

Overexposure to the active ingredient eprinomectin may cause dilated

pupils, in-coordination, drowsiness, depressed motor activity, slowed

breathing, dilation of the pupils, tremors, vomiting, anorexia, muscle

tremors, headache and dizziness.

MATERIAL SAFETY DATA SHEET

IVOMEC

®

EPRINEX

®

Pour-on

Page 1 of 7

for Beef and Dairy Cattle

Version 3

Issue Date: 13 December 2010

CHRONIC EFFECTS:

Not sensitising. In animal studies, at doses toxic to the mother, pure

eprinomectin is a reproductive toxin in mice and rats, however, in rabbits,

eprinomectin is foetotoxic at doses not toxic to the mother. Rats exposed in

utero, through lactation and for an additional 3 months, showed signs of

intravascular haemolysis.

At doses above 288 mg/kg/day of the solvent, chronic studies in rabbits and

dogs indicated testicular atrophy, also found in rats as well as foetoxicity and

teratogenicity by oral, subcutaneous and intramuscular routes.

CARCINOGEN STATUS:

Not classified by NOHSC, NTP or IARC

SECTION 3

COMPOSITION/INFORMATION ON INGREDIENTS

Ingredient

CAS No.

Content %

Classification

Risk phrase

Eprinomectin

123997-26-2

Toxic

R 20/21, 25, 50

Vehicle

confidential

>90

not classified

SECTION 4

FIRST AID MEASURES

ADVICE:

For advice, contact a Poisons Information Centre (P.I.C.) (Phone 131 126 anywhere

in Australia), or call a doctor at once.

INHALATION:

If vapour or mist inhaled, remove from contaminated area. If adverse effects occur,

contact P.I.C. or a doctor and show this MSDS.

SKIN CONTACT:

If skin or hair contact occurs, remove contaminated clothing and flush skin and hair

with running water.

EYE CONTACT:

If in eyes, hold eyelids apart and flush the eye continuously with running water.

Continue flushing until advised to stop by the Poisons Information Centre or a doctor,

or for at least 15 minutes.

INGESTION:

If swallowed urgent hospital treatment is likely to be needed. Follow instruction of

Poisons Information Centre.

Medical observation for delayed symptoms needs to be

carried out for up to 48 hours.

Medical conditions aggravated by exposure - none known.

Pharmacology:

Eprinomectin is a member of the macrocyclic lactone class of

endectocides which have a unique mode of action. Compounds of the class bind

selectively and with high affinity to glutamate-gated chloride ion channels which

occur in invertebrate nerve and muscle cells. This leads to an increase in the

permeability of the cell membrane to chloride ions with hyperpolarization of the

nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of

this class may also interact with other ligand-gated chloride channels, such as those

gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of

safety for compounds of this class is attributable to the fact that mammals do not

have glutamate-gated chloride channels, the macrocyclic lactones have a low

affinity for other mammalian ligand-gated chloride channels and they do not readily

cross the blood-brain barrier.

IVOMEC® EPRINEX®

Pour-on

Page 2 of 7

for Beef and Dairy Cattle

Version 3

Issue Date: 13 December 2010

SECTION 5

FIRE FIGHTING MEASURES

FIRE AND EXPLOSION HAZARDS:

Combustible not flammable.

EXTINGUISHING MEDIA:

Water spray/fog, dry chemical or CO2.

FIRE FIGHTING:

Do not use water jet.

Special advice in case of fire:

Emergency workers should wear full protective equipment and

supplied-air breathing apparatus. Toxic or irritant gases, vapours or

particulates may be generated in a fire. Spray water on containers

to cool them. Contain contaminated fire-fighting water.

Hazardous products of combustion:

Oxides of carbon and unidentified pyrogenic substances.

SECTION 6

ACCIDENTAL RELEASE MEASURES

IF SPILL OR LEAK IS OF SIGNIFICANT QUANTITY:

Move non-essential persons away.

Put on the protective equipment recommended in Section

8. Seal leak if safe to do so and place leaking receptacles in an over-bin. Contain spill with absorbent

material such as dry sand or kitty litter. Do not allow liquid to enter drains or sewer. Sweep up used

absorbent and pack in properly labelled container for disposal. To cleanse the contaminated area, wet down

contaminated area with a small amount of water, cover again with absorbent, sweep up used absorbent and

place in labelled container. Consult waste authority regarding disposal.

OCCUPATIONAL RELEASE: As for accidental release. Wear impervious gloves and eye protection to

deal with a large spill.

SECTION 7

HANDLING AND STORAGE

SAFETY DIRECTIONS:

PRODUCT IS HARMFUL IF SWALLOWED. WILL IRRITATE THE EYES

AND SKIN. AVOID CONTACT WITH THE EYES AND SKIN. REPEATED EXPOSURE MAY CAUSE

ALLERGIC DISORDERS.

If clothing becomes contaminated with product, remove clothing and launder. If product is on skin,

immediately wash area with soap and water. If product is in eyes, wash it out immediately with water. After

use and before eating, drinking or smoking, wash hands, arms and face thoroughly with soap and water. After

each day’s use, wash contaminated clothing.

HANDLING AND STORAGE

Store away from oxidising agents. Do not store with food. Store in original

container to protect from light. Store below 30 deg.C.

IVOMEC® EPRINEX®

Pour-on

Page 3 of 7

for Beef and Dairy Cattle

Version 3

Issue Date: 13 December 2010

SECTION 8

EXPOSURE CONTROLS/PERSONAL PROTECTION

No ingredients that require workplace atmosphere monitoring have been identified by the manufacturer.

EXPOSURE LIMITS:

NOHSC TWA = None assigned

NOHSC STEL= None assigned

No exposure limits have been established by NOHSC for ingredients such as the active ingredient.

Exposure Controls / Industrial hygiene:

VENTILATION:

Good ventilation for normal use.

RESPIRATOR:

Not required for normal use.

EYE PROTECTION:

Not required for normal use.

SKIN PROTECTION:

Not required for normal use.

Personal Protective Equipment for cleaning-up a significant spill:

EYE PROTECTION:

Use eye protection complying with AS 1336 / 1337.

SKIN PROTECTION:

Wear impervious gloves such as neoprene rubber or PVC-coated cotton gloves

complying with AS/NZS 2161.2. Wear overalls and impervious footwear. Wear a

respirator if a mist or aerosol is formed from large spills.

SECTION 9

PHYSICAL AND CHEMICAL PROPERTIES

Appearance

Colourless to yellow liquid.

Odour.

Almost none

Not relevant

Boiling point/range.

Not determined

Freezing Point

Not determined

Vapour pressure:

Not determined

Solubility in water

Poorly miscible

Specific gravity or density.

0.91 – 0.92

Flash point

220 deg.C

Autoignition temperature

Not determined

Viscosity.

Not determined

Octanol/water partition coefficient.

log Po/w = Not determined

Reactivity

Not an oxidising agent.

Burning characteristics.

Combustible, not flammable

Incompatible materials.

Strong oxidizing agents or peroxide formers.

SECTION 10

STABILITY & REACTIVITY

Thermal decomposition:

Not expected at normal temperatures.

Hazardous decomposition products:

Products of photodegradation have not been identified.

IVOMEC® EPRINEX®

Pour-on

Page 4 of 7

for Beef and Dairy Cattle

Version 3

Issue Date: 13 December 2010

Dangerous reactions:

None known.

REACTIVITY:

Stable but readily oxidised by oxidising agents such as pool and spa

chlorine, permanganates, chlorates and may catch fire in contact

with them..

CONDITIONS TO AVOID:

Contact with any oxidising agent, strong acids and strong alkali.

Incompatible with oxidising agents.

HAZARDOUS DECOMPOSITION:

No significant decomposition expected at normal temperatures.

POLYMERISATION:

No hazardous polymerisation will occur.

SECTION 11

TOXICOLOGICAL INFORMATION

This product is a veterinary medicine and should be regarded as harmful if swallowed or absorbed.

Health effects from the likely routes of exposure:

Product estimate

Eprinomectin active ingredient

LD50 acute oral rat:

> 5000 mg/kg

55 mg/kg

LD50 acute dermal rat:

> 5,000 mg/kg

>660 mg/kg

LD50 acute dermal rabbit:

>50,000 mg/kg

406 mg/kg

Inhalation 4 hr rat:

>1000 mg/L

5.11 mg/L

Skin irritation (rabbit):

Not a skin irritant

Not a skin irritant

Eye irritation (rabbit):

Eye irritant

Eye irritant

Sensitisation (guinea pig):

Not a sensitising agent

Not a sensitising agent

Genotoxicity

Not genotoxic

Not genotoxic

LOCAL EFFECTS OF PRODUCT:

None identified.

TARGET ORGANS:

Eyes

HAZARDOUS INGREDIENTS:

None

MUTAGENICITY DATA:

None available

Subacute to chronic toxicity:

None available.

Additional toxicological information:

The following symptoms may occur:

Overexposure to the active ingredient eprinomectin may cause

dilated pupils, in-coordination, drowsiness, depressed motor activity,

slowed breathing, dilation of the pupils, tremors, vomiting, anorexia,

muscle tremors, headache and dizziness.

IVOMEC® EPRINEX®

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for Beef and Dairy Cattle

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Issue Date: 13 December 2010

SECTION 12

ECOLOGICAL INFORMATION

The following Information applies to the eprinomectin active ingredient, not the product:

Environmental fate: Epronomectin photodegrades rapidly in the environment and is metabolized in the soil.

Water solubility is limited and it binds to soil very tightly. It does not bioconcentrate in fish and is not taken up

from soil into plants. Bioaccumulation potential:

Not expected to bioaccumulate.

Eprinomectin active ingredient continued

TOXICITY TO FISH:

LC50 = 1.2 ppb - Rainbow Trout - very toxic to fish.

TOXICITY TO DAPHNIA:

EC50 48 hr =

0.45 ppb (magna) - very toxic to Daphnia

TOXICITY TO ALGA:

Not available

TOXICITY TO BACTERIA:

Not available

READY BIODEGRADABILITY:

Not available

SECTION 13

DISPOSAL CONSIDERATIONS

Special precautions:

As the active ingredient is highly toxic to aquatic organisms, great care is

needed to ensure that the product does not reach a drain or waterway.

METHOD OF DISPOSAL:

Triple or (preferably) pressure rinse the empty container. Dispose of waste

product/rinsate in a disposal pit specifically marked and set up for this

purpose clear of waterways, vegetation and roots. Return clean container for

recycling where this is an option or for disposal at a landfill authorised to

accept that waste. If neither of these options are available, bury the

container below 500 mm in the disposal pit. Empty containers should not be

burned. Contaminated water can be treated by activated carbon absorption.

For the disposal of the clean-up materials from a significant spill consult

waste authority regarding disposal.

SECTION 14

TRANSPORT INFORMATION

Surface transport:

UN Number

None

UN Proper Shipping Name

None

Class and subsidiary risk

Packing Group

Special precautions for user

None

Hazchem Code

None

Labelling:

No DG Labelling required in Australia

Transport as :

No special requirements

Incompatible stowage:

Foodstuffs

IVOMEC® EPRINEX®

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for Beef and Dairy Cattle

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Issue Date: 13 December 2010

SECTION 15

REGULATORY INFORMATION

This product is registered with the Australian Pesticides and Veterinary Medicines Authority (APVMA

Approval Number 49105/)

SECTION 16

OTHER INFORMATION

Hazardous for water:

Do not allow product to reach ground water, water course or sewage system.

Poisonous to fish and plankton in water bodies.

ACRONYMS USED IN THIS MSDS

SUSDP

Standard for the Uniform scheduling of Drugs and Poisons

ADG Code

Australian Dangerous Goods (DG) Code

CAS No.

Chemical Abstracts number

UN No.

United Nations identifying number for DG

R-phrases

Risk phrases identifying main hazard of ingredient or product

S-phrases

Safety phrases identifying main safety measures to be used

NOHSC

National Occupational; Health and Safety Commission

National Toxicology Programme (USA)

IARC

International Agency for Research on Cancer

IVOMEC and EPRINEX are registered trademarks of Merial Limited.

SUPPLIER STATEMENT:

The product should be stored, handled and used in accordance with good industrial hygiene practices

and in conformity with legal regulations.. The information in this MSDS is based on the level of knowledge at the time of

preparation and relates to the product in the state in which it is supplied. The information describes the product from the safety

point of view and is not intended to guarantee any particular properties and shall not establish a legally valid contractual

relationship

IVOMEC® EPRINEX®

Pour-on

Page 7 of 7

for Beef and Dairy Cattle

Version 3

Issue Date: 13 December 2010

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