IVERMECTIN injection

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D)

Available from:

Sparhawk Laboratories, Inc.

INN (International Name):

IVERMECTIN

Composition:

IVERMECTIN 10 mg in 1 mL

Administration route:

SUBCUTANEOUS

Prescription type:

OTC

Therapeutic indications:

Cattle :  IVERMECTIN Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice and mange mites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi     (Including inhibitedO. ostertagi ) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Oesophagostomum radiatum Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice : Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mites Iscabies: Psoroptes ovis     (Syn.P. communis var.bovis ) Sarcoptes scabiei var. bovis IVERMECTIN Injection has been proved to effectively control infections and to protect cattle from reinfection withDictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment;Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment;Haemonchus placei and Cooperia oncophora for 14 days after treatment. Swine :  IVERMECTIN Injection is indicated for the effective treatment and control of the follwoing harmful species of gastrointestinal roundworms, lungworms, lice and mange mites in swine: Gastrointestinal roundworms Large roundworm,Ascaris suum (adults and fourth-stage larvae) Red stomach worm,Hyostrongylus rubidus (adults and fourth-stage larvae) Nodular worm,Oesophagostomum spp. (adults and fourth-stage larvae) Threadworm,Strongyloides ransomi (adults) Somatic Roundworm Larvae: Threadworm, Strongyloides ransomi (somtic larvae) Sows must be treated at least seven days before farrowing to prevent infection in piglets. Lungworm: Metastrongylus spp . (adults) Lice: Haematopinus suis Mange Mites: Sarcoptes scabiei  var. suis

Product summary:

50 mL, 200 mL, 500 mL The 50 mL pack is a multiple-dose, rubber-capped bottle. Each bottle contains sufficient solution to treat 10 head of 550 lb (250 kg) cattle or 100 head of 38 lb (17.3 kg) swine. The 200 mL pack is a multiple-dose, rubber-capped bottle for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 40 head of 550 lb. (250 Kg) cattle or 400 head of 38 lb. (17.3 Kg) swine. The 500 mL pack is a multiple-dose, rubber-capped bottle designed for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 100 head of 550 lb (250 kg) cattle or 1000 head of 38 lb (17.3 kg) swine. Discard any remaining volume in 200 mL, and 500 mL vial sizes following use of an automatic syringe

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

IVERMECTIN- IVERMECTIN INJECTION
SPARHAWK LABORATORIES, INC.
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IVERMECTIN INJECTION FOR CATTLE AND SWINE 1% STERILE SOLUTION
A Parasiticide for the Treatment and Control of Internal and External
Parasites of Cattle
and Swine
Consult your veterinarian for assistance in the diagnosis, treatment,
and control of
parasitism.
INTRODUCTIONIvermectin is an injectable parasiticide for cattle and
swine. One low-
volume dose effectively treats and controls the following internal and
external parasites
that may impair the health of cattle and swine: gastrointestinal
roundworms (including
inhibited _Ostertagia ostertagi_ in cattle), lungworms, grubs, sucking
lice, and mange mites
of cattle; and gastrointestinal roundworms, lungworms, lice, and mange
mites in swine.
PRODUCT DESCRIPTON
Ivermectin is derived from the avermectins, a family of potent,
broad-spectrum
antiparasitic agents isolated from fermentation of_ Streptomyces
avermitilis._IVERMECTIN
Injection is a clear, ready-to-use, sterile solution containing 1%
ivermectin, 40% glycerol
formal, and propylene glycol, q.s. ad 100%. IVERMECTIN Injection is
formulated to
deliver the recommended dose level of 200 mcg ivermectin/kilogram of
body weight in
cattle when given subcutaneously at the rate of 1 mL/110 lb (50 kg).
In Swine,
IVERMECTIN Injection is formulated to deliver the recommended dose
level of 300 mcg
ivermectin/kilogram body weight when given subcutaneously in the neck
at the rate of 1
mL/75 lbs (33 kg).
MODE OF ACTION
Ivermectin is a member of the macrocyclic lactone class of
endectocides which have a
unique mode of action. Compounds of the class bind selectively and
with high affinity to
glutamate-gated chloride ion channels which occur in invertebrate
nerve and muscle
cells. This leads to an increase in the permeability of the cell
membrane to chloride ions
with hyperpolarization of the nerve or muscle cell, resulting in
paralysis and death of the
parasite. Compounds of this class may also interact with other
ligand-gated chloride
channels, such as thos