IVERMECTIN injection, solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D)

Available from:

Durvet

INN (International Name):

IVERMECTIN

Composition:

IVERMECTIN 10 mg in 1 mL

Administration route:

SUBCUTANEOUS

Prescription type:

OTC

Therapeutic indications:

INDICATIONS Cattle : Ivermectin Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice, and mange mites in cattle. Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi ) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Oesophagostomum radiatum Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Lungworms (adults and fourth stage larvae): Dictyocaulus viviparus Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice : Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mites (scabies): Psoroptes ovis (syn. P. communis var. bovis ) Sarcoptes scabiei var. bovis Persistent Activity Ivermectin Injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus v

Product summary:

HOW SUPPLIED Ivermectin Injection for Cattle and Swine is available in three ready-to-use sizes: The 50 mL plastic bottle suitable for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 10 head of 550 lb (250 kg) cattle or 100 head of 38 lb (17.3 kg) swine. The 250 mL plastic bottle suitable for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 50 head of 550 lb (250 kg) cattle or 500 head of 38 lb (17.3 kg) swine. The 500 mL plastic bottle suitable for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 100 head of 550 lb (250 kg) cattle or 1000 head of 38 lb (17.3 kg) swine.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

IVERMECTIN- IVERMECTIN INJECTION, SOLUTION
DURVET
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IVERMECTIN
(IVERMECTIN)
INJECTION FOR CATTLE AND SWINE
1% Sterile Solution
A PARASITICIDE FOR THE TREATMENT AND CONTROL OF INTERNAL AND EXTERNAL
PARASITES OF CATTLE AND
SWINE.
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT,
AND CONTROL OF PARASITISM.
INTRODUCTION
Ivermectin (ivermectin) is an injectable parasiticide for cattle and
swine. One low-volume dose
effectively treats and controls the following internal and external
parasites that may impair the health of
cattle and swine: gastrointestinal roundworms (including inhibited
_Ostertagia ostertagi_ in cattle),
lungworms, grubs, sucking lice, and mange mites of cattle; and
gastrointestinal roundworms, lungworms,
lice, and mange mites of swine.
PRODUCT DESCRIPTION
Ivermectin is derived from the avermectins, a family of potent,
broad-spectrum antiparasitic agents
isolated from fermentation of _Streptomyces avermitilis_.
Ivermectin Injection is a clear, ready-to-use, sterile solution
containing 1% ivermectin, 40% glycerol
formal, and propylene glycol, q.s. ad 100%. Ivermectin Injection is
formulated to deliver the
recommended dose level of 200 mcg ivermectin/kilogram of body weight
in cattle when given
subcutaneously at the rate of 1 mL/110lb (50kg). In Swine, Ivermectin
Injection is formulated to deliver
the recommended dose level of 300 mcg ivermectin/kilogram body weight
when given subcutaneously
in the neck at the rate of 1 mL per 75 lb (33kg).
MODE OF ACTION
Ivermectin is a member of the macrocyclic lactone class of
endectocides which have a unique mode of
action. Compounds of the class bind selectively and with high affinity
to glutamate-gated chloride ion
channels which occur in invertebrate nerve and muscle cells. This
leads to an increase in the
permeability of the cell membrane to chloride ions with
hyperpolarization of the nerve or muscle cell,
resulting in paralysis and death of the parasite. Compounds of this
class may also interact with other
ligand-gated chloride chan