Isoptin

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Verapamil hydrochloride

Available from:

Abbott Australasia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

ISOPTIN
®

_verapamil hydrochloride_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Isoptin.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Isoptin against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT ISOPTIN IS USED
FOR
There are two types of Isoptin:
•
Isoptin tablets (available as
Isoptin 40mg, Isoptin 80mg,
Isoptin 120mg and Isoptin
160mg)
•
Isoptin SR (available as 180mg
and 240mg tablets)
The letters SR in the name Isoptin
SR stand for "sustained release". This
means the medicine is released into
the blood over an extended period of
time, usually allowing the medicine
to be taken only once a day.
Depending on your condition, your
doctor will prescribe Isoptin or
Isoptin SR.
In most parts of this leaflet, the name
Isoptin is used to refer to both Isoptin
tablets and Isoptin SR tablets. Where
there is information specific to the
type of Isoptin, the separate names
are used.
Isoptin and Isoptin SR are used in the
treatment of:
•
high blood pressure, also called
hypertension
•
angina (chest pain)
Isoptin tablets are also used to treat
irregular heartbeats, also called
arrhythmias
Your doctor may have prescribed
Isoptin for another reason. Ask your
doctor if you have any questions
about why Isoptin has been
prescribed for you.
Isoptin and Isoptin SR belong to a
group of medicines called calcium
channel blockers or calcium
antagonists. They work by opening
up blood vessels, which lets more
blood and oxygen reach the heart and
at the same time lowers high blood
pressure. Isoptin tablets also help to
control irregular heart beats.
Isoptin does not change the amount
of calcium in your blood or bones.
Calcium in your diet

Summary of Product characteristics

Isoptin Tablets 
Version 12 
11 August 2010 
1 of 16 

PRODUCT INFORMATION 

ISOPTIN
 
NAME OF THE MEDICINE 
VERAPAMIL HYDROCHLORIDE 

The chemical name of verapamil hydrochloride
is Benzeneacetonitrile, 
α - [3-[[2-(3,4-
dimethoxyphenyl) ethyl]methylamino] propyl]]-3,4-dimethoxy-
α-(1-methylethyl)-
,monohydrochloride. 

The structural formula of verapamil HCl is given below: 

It has a molecular weight of 491.07 and
the molecular formula is C
27
H
38
N
2
0
4
 • HCl . 
The CAS number: 152-11-4. 
DESCRIPTION 
Isoptin (verapamil hydrochloride) is a calcium ion
influx inhibitor (slow channel blocker or 
calcium ion antagonist).   

_ISOPTIN SR_  is available for oral administration
as light green, capsule shaped, scored, film-
coated tablets containing 240mg verapamil hydrochloride and
as light pink, capsule shaped, 
scored,
film-coated tablets containing 180mg verapamil hydrochloride.
 The tablets are designed 
for sustained release of the drug in the
gastrointestinal tract; sustained release characteristics are 
not altered when the tablet is divided in half. 

_ISOPTIN Tablets_  _(immediate release formulation)_  contain
verapamil hydrochloride 40mg or 
80mg or 120mg or 160mg as the active ingredient.
 The excipients are calcium hydrogen 
phosphate,
cellulose-microcrystalline, croscarmellose sodium, magnesium
stearate, silica-
colloidal anhydrous, hypromellose, talc-purified,
sodium lauryl sulfate, Macrogol 6000 and 
titanium dioxide. 

Verapamil hydrochloride is present as a racemic mixture
and different activities reside in the two 
enantiomers. Verapamil HCl is an almost
white, crystalline powder, practically free of odour, 
with a bitter taste.  It
is soluble in water, sparingly soluble in alcohol, and_ _practically insoluble_ _in 
ether_. _Verapamil HCl is not
chemically related to other