Country: Canada
Language: English
Source: Health Canada
LISINOPRIL
MARCAN PHARMACEUTICALS INC
C09AA03
LISINOPRIL
10MG
TABLET
LISINOPRIL 10MG
ORAL
10/100/500
Prescription
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
Active ingredient group (AIG) number: 0121550001; AHFS:
CANCELLED PRE MARKET
2021-05-13
- 1 - PRODUCT MONOGRAPH PR IPG-LISINOPRIL (lisinopril tablets, USP) Tablets 5mg, 10mg and 20 mg Angiotensin Converting Enzyme Inhibitor Marcan Pharmaceuticals Inc. Date of Revision: 77 Auriga Drive, Unit# 4 October 18, 2017 Ottawa, Ontario, K2E 7Z7 Canada Control#209657 - 2 - PRODUCT MONOGRAPH PR IPG-LISINOPRIL (lisinopril tablets, USP) Tablets 5mg, 10mg and 20 mg Angiotensin Converting Enzyme Inhibitor ACTIONS AND CLINICAL PHARMACOLOGY IPG-LISINOPRIL (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor which is used in the treatment of hypertension, congestive heart failure and following myocardial infarction in hemodynamically stable patients. ACE is a peptidyl dipeptidase which catalyzes the conversion of angiotensin I to the pressor substance, angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II, which leads to increased plasma renin activity (due to removal of negative feedback of renin release) and decreased aldosterone secretion. Although the latter decrease is small, it results in a small increase in serum potassium. In patients treated with lisinopril and a thiazide diuretic there was essentially no change in serum potassium (see PRECAUTIONS). ACE is identical to kininase II. Thus, IPG-LISINOPRIL may also block the degradation of bradykinin, a potent vasodilator peptide. However, the role that this plays in the therapeutic effects of IPG-LISINOPRIL is unknown. While the mechanism through which IPG-LISINOPRIL lowers blood pressure is believed to be primarily the suppression of the renin-angiotensin-aldosterone system (RAAS), IPG-LISINOPRIL also lowers blood pressure in patients with low-renin hypertension. PHARMACODYNAMICS Hypertension: _Adults:_ Administration of lisinopril to patients with hypertension results in a reduction of both supine and standing blood pressure. Abrupt withdrawal of lisinopril has not been associated with a rapid increase in blood pressure. In most patients studied, after oral administration of an individual dose of lisinopril, the onset of anti Read the complete document