Inderal

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Propranolol hydrochloride

Available from:

AstraZeneca Pty Ltd

Class:

Medicine Listed (Export Only)

Patient Information leaflet

INDERAL
®

_Propranolol hydrochloride_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions people ask about
INDERAL. It does not contain all the
information that is known about
INDERAL.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor will have
weighed the risks of you taking
INDERAL against the benefits they
expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT INDERAL IS FOR
INDERAL works by affecting the
body's response to some nerve
impulses, especially in the heart.
As a result, it decreases the heart's
need for blood and oxygen and
therefore reduces the amount of work
the heart has to do. It also widens the
blood vessels in the body, as well as
helping the heart to beat more
regularly.
INDERAL belongs to a group of
medicines called beta-blockers.
INDERAL tablets are used to treat or
prevent a number of conditions, most
of which are related to the heart.
•
to lower high blood pressure, also
called hypertension
•
to prevent angina
•
to treat or prevent heart attacks,
or reduce your risk of heart
problems following a heart attack
•
to treat irregularities in heart beat,
including those caused by anxiety
•
essential tremor (shaking of head,
chin, hands)
•
phaeochromocytoma
•
Fallot's Tetralogy
•
to prevent migraine headaches
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed this
medicine for another reason.
INDERAL is not addictive.
It is only available with a doctor's
prescription.
BEFORE YOU TAKE
INDERAL
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE INDERAL IF YOU HAVE
AN ALLERGY TO:
•
propranolol
•
any of the ingredient listed at the
end of this leaflet
•
any other similar medicines such
as beta-blockers
Some of the symptoms of an allergic
reaction may

Summary of Product characteristics

Inderal Product Information 
CV.000-544-237.3.0 
INDERAL 

PRODUCT INFORMATION 
NAME OF THE DRUG  
Propranolol hydrochloride BP.  The chemical name for propranolol
hydrochloride is 
2-propanol, 1- [(1-methyl-ethyl)amino]-3-(1-naphthalenyloxy),
hydrochloride, (±). 
The CAS number for propranolol hydrochloride is 318-98-9. 
The chemical structure is: 

O
CH
2
CH
CH
2
NH
CH(CH
3
)
2
*Asymmetric centre
*
.HCL
OH

DESCRIPTION 
PROPRANOLOL HYDROCHLORIDE 
Propranolol hydrochloride is an off-white to white crystalline solid
with little or no 
odour. Propranolol hydrochloride dissolves in water to the extent of
one part in 
twenty at 20°C and has a similar solubility in 95% ethanol, but is
only slightly 
soluble in chloroform. 
INDERAL TABLETS 
INDERAL is supplied as 10 and 40 tablets for oral administration.
 INDERAL 
tablets also contain lactose, gelatin, carmellose calcium, magnesium
stearate, 
hypromellose, glycerol, titanium dioxide and cochineal (CI 75470). 
INDERAL is a β-adrenoreceptor blocking agent which is structurally
related to 
other β-blocking agents such as atenolol, pindolol and oxprenolol,
differing from 
these compounds by substitution on the aromatic ring. 
PHARMACOLOGY 
Propranolol hydrochloride is a β-adrenoreceptor blocking agent which
acts non-
selectively on β-receptors (β
1
 and β
2
).  It has little intrinsic sympathomimetic 
activity.  It has some membrane stabilising effect.  INDERAL is a
racemic mixture 
and the active form is the S(-) isomer, of propranolol.  The most
important effect of 
propranolol hydrochloride is to reduce the influence of excessive
sympathetic 
nervous stimulation on the heart.  Pulse rate, force of cardiac
contraction and 
cardiac output are all reduced resulting in a significant reduction
in myocardial 
1(15) 
Inderal Product Information 
CV.000-544-237.3.0 
oxygen demand, greater than the reduction in work.  These effects,
singly or in 
combination, are of therapeutic value in several