Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
Isosorbide mononitrate
AstraZeneca Pty Ltd
Medicine Registered
IMDUR(R) 1 IMDUR(R) _Isosorbide mononitrate_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some of the common questions people ask about Imdur. It does not contain all the information that is known about Imdur. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Imdur against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT IMDUR IS FOR Imdur is used to prevent angina. Angina is a pain or uncomfortable feeling in the chest, often spreading to the arms or the neck and sometimes to the shoulders and back. This is caused by too little blood and oxygen getting to the heart. The pain of angina is usually brought on by exercise or stress. Imdur belongs to a group of medicines called nitrates. Imdur works by relaxing the blood vessels, letting more blood and oxygen reach the heart. Your doctor will have explained why you are being treated with Imdur and told you what dose to take. FOLLOW ALL DIRECTIONS GIVEN TO YOU BY YOUR DOCTOR CAREFULLY. They may differ from the information contained in this leaflet. However, your doctor may prescribe this medicine for another use. Ask your doctor if you want more information. Imdur is not addictive. BEFORE YOU USE IMDUR _WHEN YOU MUST NOT USE IT_ DO NOT USE IMDUR IF YOU ARE ALLERGIC TO IT OR FOOD CONTAINING NITRATES OR NITRITES OR ANY INGREDIENTS LISTED AT THE END OF THE LEAFLET. DO NOT USE IMDUR IF YOU HAVE THE FOLLOWING MEDICAL CONDITIONS: * Low blood pressure * Shock including those caused by low blood pressure or failing heart * Pericarditis (swelling around the heart) * Weakened muscle of the heart YOU MUST NOT USE IMDUR WHILST TAKING SILDENAFIL (VIAGRA*), VARDENAFIL (LE Read the complete document
Imdur ® Durules ® Product Information 1 (7) IMDUR ® DURULES ® PRODUCT INFORMATION (isosorbide mononitrate) DESCRIPTION IMDUR DURULES contain isosorbide mononitrate (AAN) in a sustained release formulation. The chemical name is 1,4:3,6-Dianhydro-D-glucitol 5-nitrate. Molecular formula C6H9NO6; m.w. 191.14. Isosorbide mononitrate is a white to pale yellow crystalline powder and is freely soluble in water. CAS 16051-77-7. The chemical structure of isosorbide mononitrate is: O O H H OH ON O 2 IMDUR DURULES contain the active drug embedded in a porous inert matrix consisting of paraffin-synthetic, aluminium sodium silicate, magnesium stearate, hydroxypropylcellulose and silica - colloidal anhydrous. In addition the tablet coating contains hypromellose, macrogol, titanium dioxide, hydrogen peroxide, paraffin- synthetic and water-purified. PHARMACOLOGY Isosorbide mononitrate is an active metabolite of isosorbide dinitrate and exerts qualitatively similar effects. Isosorbide mononitrate reduces the workload of the heart by producing venous and arterial dilatation. By reducing the end diastolic pressure and volume, isosorbide mononitrate lowers the intramural pressure, hence leading to an improvement in the subendocardial blood flow. The net effect when administering isosorbide mononitrate is therefore a reduced workload for the heart and an improvement in the oxygen supply/demand balance of the myocardium. Nitrates are highly effective in the prophylaxis of symptomatic and asymptomatic myocardial ischaemia. Nitrates dilate coronary arteries not only in pre- and post- stenotic vessels, but also in eccentric lesions. The natural initiator of vascular relaxation is thought to be endothelium-derived relaxing factor (EDRF), which has both the clinical and biological characteristics of nitric oxide (NO). Organic nitrates are metabolised to NO in the muscle cell via a sulfhydryl dependent mech Read the complete document