Hyzaar® Plus 10012.5mg Tablet

Country: Singapore

Language: English

Source: HSA (Health Sciences Authority)

Active ingredient:

Hydrochlorothiazide; Losartan Potassium

Available from:

ORGANON SINGAPORE PTE. LTD.

ATC code:

C09DA01

Dosage:

12.50 mg

Pharmaceutical form:

TABLET, FILM COATED

Composition:

Hydrochlorothiazide 12.50 mg; Losartan Potassium 100.0mg

Administration route:

ORAL

Prescription type:

Prescription Only

Manufactured by:

Organon Pharma (UK) Limited

Authorization status:

ACTIVE

Authorization date:

2008-03-03

Patient Information leaflet

     SG-MK0954A-T-092013

PRODUCT CIRCULAR 

Tablets 
HYZAAR® / HYZAAR® PLUS/ HYZAAR® FORTE 
(losartan potassium and hydrochlorothiazide) 

Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing 
fetus.  When pregnancy is detected, discontinue HYZAAR®/ HYZAAR® PLUS/ HYZAAR® FORTE 
as soon as possible.

I.  THERAPEUTIC CLASS 

HYZAAR®/  HYZAAR® PLUS/  HYZAAR® FORTE (losartan potassium and 
hydrochlorothiazide) is the first combination of an angiotensin II receptor (type AT
1
) 
antagonist and a diuretic.  HYZAAR®  also provides a reduction
in the risk of stroke in 
hypertensive patients with left ventricular hypertrophy. 

II.  INDICATIONS 

Hypertension 
HYZAAR®
/
  HYZAAR® PLUS/HYZAAR® FORTE is indicated for the
treatment of 
hypertension, for patients in
whom combination therapy is appropriate. 

Hypertensive Patients with Left Ventricular Hypertrophy 
HYZAAR®
/
 HYZAAR® PLUS/HYZAAR® FORTE is a combination of losartan (COZAAR) and 
hydrochlorothiazide.  In patients with hypertension and
left ventricular hypertrophy, losartan, 
often in combination with hydrochlorothiazide, reduces the
risk of stroke in hypertensive 
patients with left ventricular hypertrophy (see RACE). 

III.  DOSAGE AND ADMINISTRATION 

HYZAAR® may be administered
with other antihypertensive agents. 

HYZAAR® may be administered with or without food. 

Hypertension 
The usual starting and maintenance dose  is one
tablet of HYZAAR®  (losartan potassium 50 
mg/hydrochlorothiazide 12.5 mg) once daily.  For patients who do
not respond a

Summary of Product characteristics

SG-OG0954A-T-032022
PRODUCT CIRCULAR
Tablets
HYZAAR® / HYZAAR® PLUS / HYZAAR® FORTE
(losartan potassium and hydrochlorothiazide)
Drugs that act directly on the renin-angiotensin system can cause
injury and death to the developing
fetus. When pregnancy is detected, discontinue HYZAAR® / HYZAAR®
PLUS / HYZAAR® FORTE
as soon as possible.
I. THERAPEUTIC CLASS
HYZAAR® / HYZAAR® PLUS / HYZAAR® FORTE (losartan potassium and
hydrochlorothiazide) is the
first combination of an angiotensin II receptor (type AT
1
) antagonist and a diuretic. HYZAAR® /
HYZAAR® PLUS / HYZAAR® FORTE also provides a reduction in the risk
of stroke in hypertensive
patients with left ventricular hypertrophy.
II. INDICATIONS
Hypertension
HYZAAR® / HYZAAR® PLUS / HYZAAR® FORTE is indicated for the
treatment of hypertension, for
patients in whom combination therapy is appropriate.
Hypertensive Patients with Left Ventricular Hypertrophy
HYZAAR® / HYZAAR® PLUS / HYZAAR® FORTE is a combination of losartan
(COZAAR) and
hydrochlorothiazide. In patients with hypertension and left
ventricular hypertrophy, losartan, often in
combination with hydrochlorothiazide, reduces the risk of stroke in
hypertensive patients with left
ventricular hypertrophy (see RACE).
III. DOSAGE AND ADMINISTRATION
HYZAAR® / HYZAAR® PLUS / HYZAAR® FORTE may be administered with
other antihypertensive
agents.
HYZAAR® / HYZAAR® PLUS / HYZAAR® FORTE may be administered with or
without food.
Hypertension
The
usual
starting
and
maintenance
dose
is
one
tablet
of
HYZAAR®
(losartan
potassium
50 mg/hydrochlorothiazide
12.5 mg)
once
daily.
For
patients
who
do
not
respond
adequately
to
HYZAAR®, the dosage may be increased to one tablet of HYZAAR® FORTE
(losartan potassium
100 mg/hydrochlorothiazide 25 mg) once daily or two tablets of
HYZAAR® once daily. The maximum
dose is one tablet of HYZAAR® FORTE or two tablets of HYZAAR® once
daily. In general, the
antihypertensive effect is attained within three weeks after
initiation of therapy. HYZAAR® PLUS (losartan
potas