Hospira Cefoxitin Sodium Powder for Injection
Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
Summary of Product characteristics
(SPC)
15-05-2024
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Active ingredient:
Cefoxitin sodium
Available from:
Hospira Pty Limited
Class:
Medicine Registered
Summary of Product characteristics
Product Information – Australia
Version 1.0
Page 1
HOSPIRA™ CEFOXITIN SODIUM POWDER FOR INJECTION
NAME OF THE MEDICINE
Non proprietary name: cefoxitin sodium
Chemical name:
Sodium (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[[(thiophen-2-
yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.
Molecular formula: C
16
H
16
N
3
NaO
7
S
2
Molecular weight: 449.4
Chemical Abstracts Service (CAS) registry number: 33564-30-6
DESCRIPTION
Hospira™ Cefoxitin Sodium Powder for Injection is a white to off
white sterile powder of cefoxitin
sodium for intravenous and intramuscular administration following
reconstitution. Each vial contains
cefoxitin sodium equivalent to 1 g of Cefoxitin.
Each gram of cefoxitin sodium contains approximately 51.2 mg (2.2
mEq) of sodium. The pH of
10% w/v cefoxitin sodium in Water for Injections is 4.2 to 7.0.
PHARMACOLOGY
Cefoxitin is a bactericidal antibiotic which acts by inhibiting
bacterial cell wall synthesis. Due to the
presence of a 7-
α methoxy group in the β-lactam ring, it exhibits a high degree
of stability in the
presence of beta-lactamases.
MICROBIOLOGY
Cefoxitin is active against the following microorganisms _in
vitro_:
Aerobic bacteria
1.
Gram-positive cocci including _Staphylococci_ (including
coagulase-positive, coagulase-
negative and penicillinase producing strains), Group A beta-haemolytic
streptococci
(_Streptococcus pyogenes_), Group B beta-haemolytic streptococci
(_Streptococcus agalactiae_)
and Streptococcus pneumoniae (_Diplococcus pneumoniae_). Other
streptococci (most strains
of enterococci, e.g. _Streptococcus faecalis_) are resistant.
2.
Gram-negative cocci including _Neisseria gonorrhoeae_ (including
penicillinase-producing
strains) and _Neisseria meningitidis_.
3.
Gram-negative rods (facultative anaerobes) including _Escherichia
coli, Klebsiella _
_pneumoniae, Klebsiella_ spp, _Proteus mirabili
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