Country: Canada
Language: English
Source: Health Canada
GLYCOPYRROLATE
STERIMAX INC
A03AB02
GLYCOPYRRONIUM
0.2MG
SOLUTION
GLYCOPYRROLATE 0.2MG
INTRAMUSCULAR
10X1ML
Ethical
ANTIMUSCARINICS ANTISPASMODICS
Active ingredient group (AIG) number: 0102396002; AHFS:
APPROVED
2018-03-12
1 PRODUCT MONOGRAPH GLYCOPYRROLATE INJECTION USP 0.2 MG / ML FOR INTRAMUSCULAR OR INTRAVENOUS ADMINISTRATION ANTICHOLINERGIC SteriMax Inc. 2770 Portland Drive Oakville, Ontario L6H 6R4 Control no.: 205682 Date of Preparation: March 9, 2018 2 PRODUCT MONOGRAPH GLYCOPYRROLATE INJECTION USP 0.2 MG / ML ANTICHOLINERGIC CLINICAL PHARMACOLOGY Glycopyrrolate, like other anticholinergic (antimuscarinic) agents, competitively antagonizes the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. Glycopyrrolate antagonizes muscarinic symptoms ( e.g., bronchorrhea, bronchospasm, bradycardia and intestinal hypermotility) induced by cholinergic drugs such as anticholinesterases. As a premedicant, Glycopytrolate Injection USP reduces excessive pharyngeal, tracheal and bronchial secretions and, during anesthesia, it appears to protect the heart against excessive vagal stimulation. The polar ammonium moiety of glycopyrrolate limits its passage across lipid membranes such as the blood-brain barrier, in contrast to the belladonna alkaloids (such as atropine), which are nonpolar tertiary amines. Consequently, Glycopyrrolate Injection USP does not cause the central nervous system effects seen with the belladonna alkaloids. The onset of action following intramuscular injection of Glycopyrrolate Injection USP is 20 to 40 minutes. Peak effects occur approximately 30 to 45 minutes after administration and the duration of action ranges from 4 to 6 hours. With intravenous injection, the onset of action is generally evident within one minute; the duration of action varies, as does that of all other anticholinergics. Following intravenous glycopyrrolate, the vagal blocking effects persist for 2 to 3 hours and the antisialagogue effects persist up to 7 hours. 3 INDICATIONS GASTROINTESTINAL DISORDERS : Glycopyrrolate Injection USP may be used in the management of gastrointestinal disorders amenable to anticholinergic therapy wh Read the complete document