GANTIN gabapentin 400mg capsule blister pack

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

gabapentin

Available from:

Upjohn Australia Pty Ltd

Authorization status:

Registered

Patient Information leaflet

GANTIN
®
(GAN-TIN)
_gabapentin (gab-a-pen-tin)_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Gantin.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Gantin against
the benefits it is expected to have for
you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT GANTIN IS USED
FOR
_WHAT GANTIN DOES_
Gantin is used to control epilepsy.
Epilepsy is a condition where you
have repeated seizures (fits). There
are many different types of seizures,
ranging from mild to severe.
Gantin is also used to treat
neuropathic pain, a type of pain
caused by damage to the nerves.
This medicine belongs to a group of
medicines called anticonvulsants.
_HOW GANTIN WORKS_
This medicine is thought to work by
controlling brain chemicals which
send signals to nerves to help control
seizures or neuropathic pain.
Gantin also has pain relieving effects.
Your doctor may have prescribed
Gantin in addition to other medicines
that you may be taking. This may be
necessary if your current treatment is
no longer working as well.
Your doctor may have prescribed
Gantin for another reason.
Gantin may lead to dependence on
this medicine.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
This medicine is available only with
a doctor's prescription.
_USE IN CHILDREN_
There is not enough information to
recommend the use of this medicine
in children:
•
under the age of 3 years to control
epilepsy, or
•
under the age of 18 years to treat
neuropathic pain.
BEFORE YOU TAKE
GANTIN
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE GANTIN IF YOU HAVE AN
ALLERGY TO:
•
any medicine containing
gabapentin, the active ingredient
in Gantin
•
any of the ingredients listed at the
end of this leaflet.
Some of the s

Summary of Product characteristics

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PRODUCT INFORMATION
GANTIN
® (GABAPENTIN)
NAME OF THE MEDICINE
GANTIN (gabapentin) 100 mg, 300 mg and 400 mg capsules.
GANTIN (gabapentin) 800 mg tablets.
GANTIN contains the active ingredient gabapentin. The structural
formula of gabapentin is shown
below:
CH
2
NH
2
CH
2
C O
2
H
Chemical name:
1-(aminomethyl) cyclohexaneacetic acid
Molecular formula:
C
9
H
17
NO
2
Molecular weight:
171.24
CAS Registry Number:
60142-96-3.
DESCRIPTION
Gabapentin is a white to off-white crystalline solid. It is freely
soluble in water and both basic and
acidic aqueous solutions.
GANTIN capsules also contain the following inactive ingredients:
lactose monohydrate, purified
talc, maize starch, gelatin and titanium dioxide. The 300 mg capsule
also contains iron oxide yellow
and the 400 mg capsule also contains both iron oxide yellow and iron
oxide red.
GANTIN tablets also contain the following inactive ingredients:
poloxamer, copovidone, maize
starch, magnesium stearate, candelilla wax and Opadry white
YS-1-18111.
PHARMACOLOGY
PHARMACODYNAMICS
The mechanism by which gabapentin exerts its anticonvulsant action is
unknown. Gabapentin is
structurally related to the neurotransmitter GABA (gamma-aminobutyric
acid) but its mechanism of
action is different from that of several other drugs that interact
with GABA synapses including
valproate, barbiturates, benzodiazepines, GABA transaminase
inhibitors, GABA uptake inhibitors,
GABA
agonists,
and
GABA
prodrugs.
_In _
_vitro_
studies
with
radiolabelled
gabapentin
have
characterised a novel peptide binding site in rat brain tissues
including neocortex and hippocampus
that may relate to anticonvulsant activity of gabapentin and its
structural derivatives. However, the
identification and function of the gabapentin binding site remains to
be elucidated. Gabapentin at
relevant clinical concentrations does not bind to other common drug or
neurotransmitter receptors of
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the brain