FUROSEMIDE- furosemide injection

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

FUROSEMIDE (UNII: 7LXU5N7ZO5) (FUROSEMIDE - UNII:7LXU5N7ZO5)

Available from:

Clipper Distributing Company, LLC.

INN (International Name):

FUROSEMIDE

Composition:

FUROSEMIDE 50 mg in 1 mL

Administration route:

INTRAMUSCULAR

Prescription type:

PRESCRIPTION

Therapeutic indications:

Dogs and Horses: Furosemide Injection is an effective diuretic-saluretic for use in the treatment of acute noninflammatory tissue edema in dogs and horses, and for use in the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency in the dog. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy in either dogs or horses is determined by the clinical pathology producing the edema. Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant bitches, mares and stallions at stud. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. Monitor serum electrolytes, BUN and CO2 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia. Corticosteroids cause an additive potassium-depletion effect.

Product summary:

Furosemide Injection, 50 mg/mL is supplied in 100 mL multi-dose vials. NDC 57319-450-05 – 100 mL

Authorization status:

New Animal Drug Application

Summary of Product characteristics

FUROSEMIDE- FUROSEMIDE INJECTION
CLIPPER DISTRIBUTING COMPANY, LLC.
----------
FUROSEMIDE INJECTION
50 MG/ML
NADA 131-538, Approved by FDA
CAUTION:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DES CRIPTION:
Furosemide is a potent loop diuretic which is a derivative of
anthranilic acid. The structure is:
Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid.
Furosemide is pharmacodynamically
characterized by the following:
1) Administered intramuscularly, it begins to act in about 30 minutes,
and diuretic response is produced.
When administered intravenously, the response is in about 5 minutes.
2) Is a loop diuretic which inhibits reabsorption of sodium and
chloride at the ascending loop of Henle
in the kidneys, enhancing water excretion.
3) A dose-response relationship and a ratio of minimum to maximum
effective dose range greater than
tenfold.
4) A high degree of efficacy, low inherent toxicity and a high
therapeutic index.
EACH ML CONTAINS: 50 mg furosemide as a monoethanolamine salt,
myristyl-gamma-picolinium chloride
0.02%, EDTA sodium 0.1%, sodium sulfite 0.1% with sodium chloride 0.2%
in water for injection, pH
adjusted with sodium hydroxide and/or hydrochloric acid.
ACTIONS :
The therapeutic efficacy of Furosemide Injection is from the activity
of the intact and unaltered
molecule throughout the nephron, inhibiting the reabsorption of sodium
not only in the proximal and
distal tubule but also in the ascending limb of the loop of Henle. The
prompt onset of action is a result
of the drug’s rapid absorption and a poor lipid solubility. The low
lipid solubility and a rapid renal
excretion minimize the possibility of its accumulation in tissues and
organs or crystalluria. Furosemide
has no inhibitory effect on carbonic anhydrase or aldosterone activity
in the distal tubule. The drug
possesses diuretic activity either in the presence of acidosis or
alkalosis.
INDICATIONS :
Dogs and Horses: Furosemide Injection is an effective
diuretic-saluretic for use in the t