Country: United States
Language: English
Source: NLM (National Library of Medicine)
ESZOPICLONE (UNII: UZX80K71OE) (ESZOPICLONE - UNII:UZX80K71OE)
Preferred Pharmaceuticals Inc. USA
ORAL
PRESCRIPTION DRUG
Eszopiclone tablets are indicated for the treatment of insomnia. In controlled outpatient and sleep laboratory studies, eszopiclone tablets administered at bedtime decreased sleep latency and improved sleep maintenance. The clinical trials performed in support of efficacy were up to 6 months in duration. The final formal assessments of sleep latency and maintenance were performed at 4 weeks in the 6-week study (adults only), at the end of both 2-week studies (elderly only) and at the end of the 6-month study (adults only). Risk Summary Available pharmacovigilance data with eszopiclone use in pregnant women are insufficient to identify a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. In animal reproduction studies conducted in pregnant rats and rabbits throughout organogenesis, there was no evidence of teratogenicity. Administration of eszopiclone to rats throughout pregnancy and lactation resulted in offspring toxicities at all doses tested; the lowest dose wa
Eszopiclone Tablets, USP, 2 mg are round, white to off-white, film-coated, and identified with debossed markings of ‘383’ on one side, and ‘G’ on the other side and are supplied as: Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°F to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].
Abbreviated New Drug Application
ESZOPICLONE- ESZOPICLONE TABLET, FILM COATED Preferred Pharmaceuticals Inc. USA ---------- MEDICATION GUIDE Eszopiclone (ES-zoe-PIK-lone) Tablets, Coated C-IV Read the Medication Guide that comes with eszopiclone tablets before you start taking them and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your doctor about your medical condition or treatment. What is the most important information I should know about eszopiclone tablets? • Do not take more eszopiclone tablets than prescribed. Eszopiclone tablets may cause serious side effects including: Complex sleep behaviors that have caused serious injury and death. After taking eszopiclone tablets, you may get up out of bed while not being fully awake and do an activity that you do not know you are doing (complex sleep behaviors). The next morning, you may not remember that you did anything during the night. These activities may occur with eszopiclone tablets whether or not you drink alcohol or take other medicines that make you sleepy. Reported activities and behaviors include: • doing activities when you are asleep like: Stop taking eszopiclone tablets and call your healthcare provider right away if you find out that you have done any of the above activities after taking eszopiclone tablets. The morning after you take eszopiclone tablets your ability to drive safely and think clearly may be decreased. You also may experience sleepiness during the day. Do not take eszopiclone tablets if you: • have ever experienced a complex sleep behavior (such as driving a car, making and eating food, talking on the phone or having sex while not fully awake) after taking eszopiclone tablets. What are eszopiclone tablets? Eszopiclone tablets are a sedative-hypnotic (sleep) medicine. Eszopiclone tablets are used in adults for the treatment of a sleep problem called insomnia. Symptoms of insomnia include: • trouble falling asleep Eszopiclone tablets are not for children. Eszopiclone is a federally contro Read the complete document
ESZOPICLONE- ESZOPICLONE TABLET, FILM COATED PREFERRED PHARMACEUTICALS INC. USA ---------- HIGHLIGHTS OF PRESCRIBING INFORMATION THESE HIGHLIGHTS DO NOT INCLUDE ALL THE INFORMATION NEEDED TO USE ESZOPICLONE TABLETS SAFELY AND EFFECTIVELY. SEE FULL PRESCRIBING INFORMATION FOR ESZOPICLONE TABLETS. ESZOPICLONE TABLETS, FOR ORAL USE, CIV INITIAL U.S. APPROVAL: 2004 WARNING: COMPLEX SLEEP BEHAVIORS _SEE FULL PRESCRIBING INFORMATION FOR COMPLETE BOXED WARNING._ COMPLEX SLEEP BEHAVIORS INCLUDING SLEEP-WALKING, SLEEP-DRIVING, AND ENGAGING IN OTHER ACTIVITIES WHILE NOT FULLY AWAKE MAY OCCUR FOLLOWING USE OF ESZOPICLONE TABLETS. SOME OF THESE EVENTS MAY RESULT IN SERIOUS INJURIES, INCLUDING DEATH. DISCONTINUE ESZOPICLONE TABLETS IMMEDIATELY IF A PATIENT EXPERIENCES A COMPLEX SLEEP BEHAVIOR (4, 5.1). RECENT MAJOR CHANGES INDICATIONS AND USAGE Eszopiclone tablets are indicated for the treatment of insomnia. Eszopiclone tablets have been shown to decrease sleep latency and improve sleep maintenance (ERROR! HYPERLINK REFERENCE NOT VALID.). (1) DOSAGE AND ADMINISTRATION • • • • • DOSAGE FORMS AND STRENGTHS Tablets: 1 mg, 2 mg, and 3 mg (ERROR! HYPERLINK REFERENCE NOT VALID.) (3) CONTRAINDICATIONS • • WARNINGS AND PRECAUTIONS • • • • • • Boxed Warning 08/2019 Use the lowest dose effective for the patient (ERROR! HYPERLINK REFERENCE NOT VALID.) Recommended initial dose is 1 mg, immediately before bedtime, with at least 7 to 8 hours remaining before the planned time of awakening. May increase dose if clinically indicated, to a maximum of 3 mg (ERROR! HYPERLINK REFERENCE NOT VALID.) Geriatric or debilitated patients: Dose should not exceed 2 mg (ERROR! HYPERLINK REFERENCE NOT VALID.) Patients with severe hepatic impairment, or taking potent CYP3A4 inhibitors: Dose should not exceed 2 mg (ERROR! HYPERLINK REFERENCE NOT VALID.) Do not take with or immediately after a meal (ERROR! HYPERLINK REFERENCE NOT VALID.) Patients who have experienced complex sleep behaviors after taking eszopiclone tablets (_4_) Known Read the complete document