EPRIZERO- eprinomectin solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

eprinomectin (UNII: 75KP30FD8O) (eprinomectin - UNII:75KP30FD8O)

Available from:

Norbrook Laboratories Limited

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

Eprizero (eprinomectin) Pour-On is indicated for the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi ), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle. Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, Eprizero Pour-On is indicated for the effective treatment and control of the following parasites. Gastrointestinal Roundworms Lungworms Cattle Grubs (all parasitic stages) Hypoderma lineatum, Hypoderma bovis Lice Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus Mange Mites Chorioptes bovis, Sarcoptes scabiei Horn Flies Haematobia irritans Eprizero (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days

Product summary:

Eprizero (eprinomectin) Pour-On for Beef and Dairy Cattle is available in a 1 L/33.8 fl oz container with a measure-squeeze-pour system, or in a 2.5 L/84.5 fl oz or 5 L/169 fl oz container or 20 L/676 fl oz container intended for use with appropriate automatic dosing equipment. Made in the UK. Manufactured by: Norbrook Laboratories Limited Newry, BT35 6PU, Co. Down, Northern Ireland. ® Eprizero is a registered trademark of Norbrook Laboratories Limited. Rev. October 2020 121670I04 Norbrook ®

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

EPRIZERO- EPRINOMECTIN SOLUTION
NORBROOK LABORATORIES LIMITED
----------
Approved by FDA under ANADA # 200-563
EPRIZERO
(EPRINOMECTIN)
POUR-ON for Beef and Dairy Cattle
PARASITICIDE
Contains 5 mg eprinomectin/mL
NOT FOR USE IN CALVES TO BE PROCESSED FOR VEAL.
INTRODUCTION
Eprizero
Pour-On delivers effective internal and external parasite control in
one
application. Eprizero Pour-On contains eprinomectin, a unique
avermectin. Its broad-
spectrum efficacy in a weatherproof formulation, margin of safety,
zero slaughter
withdrawal and zero milk discard, make it a convenient product for
parasite control in
beef and dairy cattle, including lactating dairy cattle.
MODE OF ACTION
Eprinomectin is a member of the macrocyclic lactone class of
endectocides which have a
unique mode of action. Compounds of the class bind selectively and
with high affinity to
glutamate-gated chloride ion channels which occur in invertebrate
nerve and muscle
cells. This leads to an increase in the permeability of the cell
membrane to chloride ions
with hyperpolarization of the nerve or muscle cell, resulting in
paralysis and death of the
parasite. Compounds of this class may also interact with other
ligand-gated chloride
channels, such as those gated by the neurotransmitter
gamma-aminobutyric acid
(GABA). The margin of safety for compounds of this class is
attributable to the fact that
mammals do not have glutamate-gated chloride channels, the macrocyclic
lactones have
a low affinity for other mammalian ligand-gated chloride channels and
they do not readily
cross the blood-brain barrier.
INDICATIONS
Eprizero (eprinomectin) Pour-On is indicated for the treatment and
control of
gastrointestinal roundworms (including inhibited _Ostertagia
ostertagi_), lungworms,
grubs, sucking and biting lice, chorioptic and sarcoptic mange mites,
and horn flies in
beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body
weight, to achieve
a dose level of 500 mcg eprinomectin/kg body weig