Egocort

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Hydrocortisone

Available from:

Ego Pharmaceuticals Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

EGO EGOCORT CREAM 1%
1
EGO EGOCORT CREAM 1%
_Hydrocortisone 1 % w/w_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Egocort Cream 1%.
It does not contain all the available
information.
It does not take the place of talking
to your doctor or pharmacist.
If you have any concerns about this
medicine, ask your doctor or
pharmacist.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
PRODUCT NAME
The name of your medicine is
Egocort Cream 1%. Aust R 10618
ACTIVE INGREDIENT AND
CONTENT
Egocort Cream 1% contains
hydrocortisone 1 %w/w as the active
ingredient.  It also contains benzyl
alcohol, cetyl alcohol, cetostearyl
alcohol, macrogol 400, propylene
glycol, cetomacrogol 1000, glyceryl
monostearate self-emulsifying, &
water.
ACTION (PHARMACOLOGY)
The active ingredient in Egocort
Cream 1%, hydrocortisone, reduces
inflammation and itching.  It is used
for the relief of symptoms associated
with conditions such as dermatitis,
eczema and psoriasis.
USES (INDICATIONS)
Egocort Cream 1% is used on the
skin to relieve the redness, swelling,
itching and discomfort of many skin
problems such as:
*
eczema
*
psoriasis
*
dermatitis
Your doctor or pharmacist, however,
may have recommended Egocort
Cream 1% for another purpose.
SIDE EFFECTS
Egocort Cream 1% helps most
people with skin problems but it may
have unwanted side effects in a few
people.
Side effects that have been reported
by some people using cortisones
include:
*
slight stinging sensation
*
itching
*
redness
*
allergy
*
thinning of the skin
IF YOU HAVE THESE OR ANY OTHER SIDE
EFFECTS, CHECK WITH YOUR DOCTOR OR
PHARMACIST.
Do not be alarmed by this list of
possible side effects.  You may not
experience any of them.
PRECAUTIONS / WARNINGS
Egocort Cream 1% reduces
inflammation and itching.  As a
result, signs of infection may be
masked.  The area being treated
should b

Summary of Product characteristics

PRODUCT INFORMATION
EGOCORT CREAM 1%
1% W/W HYDROCORTISONE DISSOLVED TO FACILITATE PENETRATION
DESCRIPTION
Hydrocortisone is the main glucocorticoid secreted by the adrenal
cortex.  It has properties qualitatively
similar to those of cortisone acetate, although hydrocortisone is
pharmacologically active whereas
cortisone must be converted in the liver to hydrocortisone.
Chemical Name:
11
β,17α,21-trihydroxypregn-4-ene-3,20-dione
Molecular Formula: C
21
H
30
O
5
Structural Formula:
Egocort Cream 1% contains 10 mg/g of hydrocortisone in an
occlusive cream base.  The hydrocortisone is
dissolved before being added to the base in order to ensure an
even distribution throughout the vehicle.
PHARMACOLOGY
Egocort Cream 1% is pharmacologically more active than
other hydrocortisone creams of the same
strength in causing vasoconstriction, as shown in a
study by R. Woodford and B.W. Barry, U.K., 1984-5.
The active component, hydrocortisone, has
anti-inflammatory, anti-eczematous, anti-allergic and anti-
pruritic properties.
Metabolism:  Hydrocortisone is metabolised in the
liver most likely by reduction of the 5,6 double bond and
the C3 and C20 keto groups.  The resultant hydroxy derivatives are
then conjugated with glucuronic acid.
Hydrocortisone, an 11-keto-steroid is formed
from hydrocortisone; the 11-keto-steroids are then reduced
and conjugated to yield glucuronide metabolites.  A small percentage
of hydrocortisone is converted to the
17-keto-steroid.  The C21 hydroxyl group is conjugated
with sulphate.
Excretion:  When radioactive-carbon, ring-labelled steroids are
injected intravenously in man, most of the
radioisotope is recovered in the urine within 72 hours. 
Neither biliary nor faecal excretion is of any
quantitative importance in man.  It has been estimated that the
liver metabolises at least 70% of the
hydrocortisone secreted.
INDICATIONS
Egocort cream 1% is indicated for topical application
for adjunctive therapy