E-Mycin

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Erythromycin ethyl succinate

Available from:

Alphapharm Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

E-MYCIN

_contains the active ingredient erythromycin (ethylsuccinate)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about E-Mycin tablets and
mixtures.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking E-Mycin against
the benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT E-MYCIN IS USED
FOR
E-Mycin is used to:
•
treat certain bacterial infections
•
control acne, in addition to other
acne treatments
•
prevent infections in people with
a history of rheumatic disease,
who are allergic to penicillin
antibiotics.
E-Mycin is an antibiotic that belongs
to a group of medicines called
macrolides. These medicines work
by killing or stopping the growth of
bacteria, which cause infections or
make acne worse.
E-Mycin will not work against
infections caused by viruses, such as
colds or flu.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY E-MYCIN HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed E-
Mycin for another reason.
E-Mycin is available only with a
doctor's prescription.
There is no evidence that E-Mycin is
addictive.
BEFORE YOU TAKE E-
MYCIN
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE E-MYCIN IF YOU ARE
ALLERGIC TO:
•
medicines containing
erythromycin (eg. EES) or any
other antibiotic from the
macrolide group
•
any of the ingredients listed at the
end of this leaflet.
Some of the symptoms of an allergic
reaction may include skin rash,
itching or hives; swelling of the face,
lips, tongue or other parts of the
body; shortness of breath, wheezing
or troubled breathing.
DO NOT TAKE E-MYCIN IF YOU HAVE
SEVERE LIVER PROBLEMS.
DO NOT TAKE E-MYCIN IF YOU ARE
TAKING ANY OF THE FOLLOWING
MEDICINES:
•
cisapride (Prepulsid)
•
pimozide (Orap).
•
erg

Summary of Product characteristics

E-MYCIN 
_Erythromycin (ethylsuccinate)_ 

PRODUCT INFORMATION 

NAME OF THE MEDICINE 
The active ingredient of E-Mycin tablets and
granules is erythromycin (as ethylsuccinate). 

Molecular formula: 
C
43
H
75
NO
16 
Molecular weight: 
862.1 
CAS Registry no.: 
41342-53-4 
DESCRIPTION 
Erythromycin is produced by a strain
of _Streptomyces erythraeus_  and belongs to the macrolide
group of 
antibiotics.  It is a base and readily forms salts with acids. 
The base, the stearate salt and the esters are poorly 
soluble in water.  Erythromycin ethylsuccinate is an
ester of erythromycin suitable for oral administration. 
The tablets are intended primarily for adult use.  The
granules are intended for constitution with water.  When 
constituted, they are cherry flavoured suspensions intended
primarily for paediatric use but can also be used by 
adults. 
E-Mycin tablets contain the
following inactive ingredients: calcium hydrogen phosphate
anhydrous, maize starch, 
sorbic acid, povidone, purified talc, sodium starch
glycollate, magnesium stearate and Opadry Pink OY-B-34901. 
E-Mycin granules contain the following inactive
ingredients: sorbitol, propylene
glycol alginate, sodium citrate, 
aspartame, sodium benzoate
(preservative), colloidal anhydrous silica, erythrosine CI 45430
and cherry flavour. 
PHARMACOLOGY 
_ACTIONS IN MAN._  The mode of action of erythromycin has been
well characterised.  Erythromycin binds to the 
50S ribosomal subunits of susceptible bacteria to inhibit protein
synthesis without affecting nucleic acid synthesis. 
PHARMACOKINETICS 
Erythromycin ethylsuccinate is absorbed intact following
oral administration, and undergoes hydrolysis to yield the 
active erythromycin base.  Serum levels are comparable when
administered to patients in either the fasting or 
nonfasting state.  Individual peak serum levels are
variable; the peak�