Drontal Cat Tablets

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

PRAZIQUANTEL; PYRANTEL EMBONATE

Available from:

ELANCO MALAYSIA SDN BHD

INN (International Name):

PRAZIQUANTEL; PYRANTEL EMBONATE

Units in package:

40.00 mcg/mL; 48 Tablets

Manufactured by:

KVP Pharma + Veterinar Produkte GmbH

Summary of Product characteristics

502169APK
Drontal Cat Tablets
90208570
Leaflet
LBAH
N/A
90204266
148 x 210 mm
N/A
TPM_016192
7 pt
ORT / MK / 28.03.2022
V1
Laetus: 0025
N/A
BLACK
DIE LINE
Cat Tablets
Treatment for gastrointestinal
roundworms and tapeworms in cats
PRODUCT DESCRIPTION
DRONTAL™ CAT TABLETS is a white to yellowish colour coated tablet.
Each tablet contains 230 mg of pyrantel embonate (equivalent to
80 mg pyrantel) and 20 mg of praziquantel.
PHARMACODYNAMICS
Pyrantel acts as cholinergic agonist. Its mode of action is to
stimulate
nicotinic cholinergic receptors of the parasite, induce spastic
paralysis
and thereby allow expulsion from the gastrointestinal (GI) system by
peristalsis.
Praziquantel is very rapidly absorbed into and distributed throughout
the parasite. Both in vivo and in vitro studies have shown that
praziquantel causes severe damage to the parasite integument,
resulting in contraction and paralysis. There is an almost
instantaneous
tetanic contraction of the parasite musculature and a rapid
vacoulisation of the syncytial tegument. This rapid contraction has
been explained by changes in divalent cation fluxes, especially
calcium.
In this fixed combination product pyrantel is active against the
following ascarids:
Toxocara cati
and
Toxascaris leonina.
Praziquantel
is effective against tapeworms, in particular
Dipylidium caninum
and
Taenia taeniaformis.
PHARMACOKINETICS
Praziquantel is absorbed very rapidly and almost completely in the
stomach and small intestine following oral administration to all
species
investigated. Maximum serum levels are already reached within 0.3 to
2 hours. Praziquantel is very rapidly distributed into all organs. The
elimination half-lives of 14C-praziquantel and its metabolites are
between 2 and 3 hours in all investigated species. Praziquantel is
rapidly metabolised in the liver. In addition to other metabolites,
the
main metabolite occurring in each case is the 4-hydroxycyclohexyl
derivative of praziquantel. Praziquantel is completely eliminated
within 48 hours in the form of its metabolit