Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Cont_eth
DOXYMYCIN®–100 CAPSULES DOXYMYCIN®–100 TABLETS SCHEDULING STATUS: S4 PROPRIETARY NAME (and dosage form): DOXYMYCIN ® –100 CAPSULES DOXYMYCIN ® –100 TABLETS COMPOSITION: Capsules Each capsule contains: Doxycycline hydrochloride equivalent to 100 mg doxycycline. Tablets Each tablet contains: Doxycycline hydrochloride equivalent to 100 mg doxycycline. PHARMACOLOGICAL CLASSIFICATION: A 20.1.1 Broad and medium spectrum antibiotics. PHARMACOLOGICAL ACTION: Doxycycline hydrochloride is a tetracycline which is a broad spectrum antibiotic. It is bacteriostatic against susceptible strains of a wide range of Gram-positive and Gram-negative organisms. Doxycycline is useful in infections caused by Haemophilus ducreyi, Brucella (in conjunction with Streptomycin), Vibrio cholerae, Pseudomonas (actinobacillus) mallei and pseudomallei, and Calyminatobacterium (Danovania) granulomatis. Doxycycline also inhibits the growth of Yersinia (Pasteurella) pestis, Francisella (Past.) tularensis and Past. multocida. More variable success is achieved with infections due to Escherichia coli, Klebsiella, Enterobacter (Aerobacter), Bacteroides, H. influenzae and indole-producing strains of Proteus. Doxycycline is effective against certain rickettsiae and larger viruses responsible for Rocky Mountain spotted fever, murine typhus, epidemic typhus, scrub typhus, rickettsial pox and Q fever. Doxycycline is also effective in relapsing fever (Borrelia recurrentis) and is a valuable secondary agent against the spirochetes Treponema pallidum, T. pertenue, and Leptospira interrogans. High concentrations inhibit the growth of the protozoen Entamoeba histolytica. Certain organisms known to have been sensitive may have lost their sensitivity to tetracycline. Many strains of staphylococci and enterococci and nearly al Read the complete document