Country: Canada
Language: English
Source: Health Canada
CLOBETASOL PROPIONATE
TAROPHARMA, A DIVISION OF TARO PHARMACEUTICALS INC.
D07AD01
CLOBETASOL
.05%
OINTMENT
CLOBETASOL PROPIONATE .05%
TOPICAL
50G
Prescription
ANTI-INFLAMMATORY AGENTS
Active ingredient group (AIG) number: 0110995001; AHFS:
APPROVED
2003-09-03
Prescribing Information Pr DERMOVATE ® Cream (clobetasol propionate cream, USP) Pr DERMOVATE ® Ointment (clobetasol propionate ointment, USP) Topical corticosteroid TaroPharma Preparation Date: A Division of Taro Pharmaceuticals Inc. Sept 02, 2003 130 East Drive Brampton, Ontario Revision Date: L6T 1C1 August 6, 2003 Control # 086321 1 Prescribing Information Pr DERMOVATE ® Cream (clobetasol propionate cream, USP) Pr DERMOVATE ® Ointment (clobetasol propionate ointment, USP) Topical Corticosteroid Actions and Clinical Pharmacology The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasol propionate are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, anti-pruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain. Clobetasol propionate has been shown to have topical and systemic pharmacologic and metabolic effects characteristic of the corticosteroid class of drugs. 2 Indications and Clinical Use DERMOVATE (clobetasol propionate) Cream and Ointment are indicated for the topical therapy of recalcitrant corticosteroid-responsive dermatoses, including severe cases of psoriasis (excluding widespread plaque psoriasis) and eczematous dermatitis. Contraindications DERMOVATE (clobetasol propionate) cream and ointment are not indicated for the treatment of rosacea, acne vulgaris, perioral dermatitis or perianal and genital pruritus. These preparations are contraindicated also in the treatment of primary infected bacterial or fungal skin lesions if no anti-infective agent is used simultaneously, in primary cutaneous viral infections (i.e., herpes simplex, vaccinia and v Read the complete document