Creon Micro

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Pancreatic extract

Available from:

Abbott Australasia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

CREON
®
 MICRO

_Pancreatic Extract Enteric-Coated Granules_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions about Creon
Micro. It does not contain all of the
available information. It does not
take the place of talking to your
doctor or pharmacist.
PLEASE READ THIS LEAFLET BEFORE YOU
START TAKING CREON MICRO.
If you are helping someone else to
take Creon Micro, please read this
leaflet before you give the first dose.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Creon Micro
against the benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING CREON MICRO, ASK YOUR
DOCTOR OR PHARMACIST.
Your doctor and pharmacist have
more information.
KEEP THIS LEAFLET WITH YOUR CREON
MICRO.
You may need to read it again.
WHAT CREON MICRO IS
USED FOR
Creon Micro is a pancreatic enzyme
supplement used in a condition called
pancreatic exocrine insufficiency
where the body does not make
enough enzymes to digest food. This
condition appears in a number of
different patients including those
with cystic fibrosis, chronic
pancreatitis, or patients who have had
upper gastrointestinal surgery. People
with a deficiency of pancreatic
enzymes often suffer with symptoms
of diarrhoea, steatorrhoea (foul fatty
stools which float in the toilet),
bloating and weight loss. These
symptoms appear because the body is
unable to digest food normally.
When this happens your body's
ability to absorb important nutrients
from food is impaired and leads to
malnutrition. If left untreated, these
symptoms can affect your quality of
life and a poor nutritional status
could have long term health
implications. The supplementation of
pancreatic enzymes using Creon
helps restore the normal digestive
action in your body to relieve
abdominal symptoms and improve
nutritional status.
The enzymes are extracted from
pancreas of pigs.
Creon Micro is approved for the uses
listed above. However, your doctor
may prescribe this medicine for
another use. I

Summary of Product characteristics

_Creon Micro PI_
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PRODUCT INFORMATION 
CREON
®
 MICRO ENTERIC-COATED GRANULES 
NAME OF THE MEDICINE 
NON-PROPRIETARY NAME 
Pancreatic Extract  
DESCRIPTION 
Creon  Micro  are porcine pancreatic enzyme
preparations containing Pancreatic Extract 
encapsulated in enteric-coated granules with a pH-sensitive
coating.   
Each dosing unit of 100 mg of Creon
Micro contains Pancreatic Extract 60,12 mg equivalent 
to not less than
5,000 BP units lipase, 3,600 BP units amylase and 200 Ph. Eur. units 
protease.  Inactive ingredients include macrogol 4000, hypromellose phthalate, dimethicone 
1000 triethyl citrate, cetyl alcohol. One dosage
unit is measured with a measuring scoop as 
dosing device.  
PHARMACOLOGY 
Administered orally, pancreatic extract assists in the digestion
of proteins, carbohydrates 
and fats. 
Creon Micro has been specially formulated to combine the
features of rapid homogeneous 
distribution with the chyme in the stomach, with
resistance to inactivation by gastric acid 
and rapid dissolution in the alkaline pH of the
duodenum.  When the granules  reach the 
small intestine the coating rapidly disintegrates (at pH > 5.5) to
release enzymes with 
lipolytic, amylolytic and proteolytic activity to ensure
the digestion of fats, starches and 
proteins. The products of pancreatic digestion are then either absorbed directly, or following 
further hydrolysis by intestinal enzymes.  The granules are similar in size
to food particles 
(0.7-1 mm in diameter), and mix homogeneously with the chyme while being protected from 
inactivation by gastric acid (pH 1) for up to 2 hours. 
They pass into the alkaline pH of the 
duodenum at least as quickly as the food
they are intended to digest; here the enteric-
coating rapidly dissolves releasing enzymes at the appropriate
site.�