Condropil capsule

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

Glucosamine Sulfate Sodium, Crystalline; Chondroitin Sulphate 90% (Shark Source)

Available from:

AV MANUFACTURING SDN.BHD

INN (International Name):

Glucosamine Sulfate Sodium, Crystalline; Chondroitin Sulphate 90% (Shark Source)

Units in package:

60Capsule Capsules

Manufactured by:

AV MANUFACTURING SDN.BHD

Patient Information leaflet

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
CONDROPIL
®
CAPSULE
Glucosamine Sulphate/Chondroitin Sulphate (250mg/200mg)
1
WHAT IS IN THIS LEAFLET
1.
What Condropil is used for
2.
How Condropil works
3.
Before you take Condropil
4.
How to use Condropil
5.
While you are using Condropil
6.
Side effects
7.
Storage and disposal
8.
Product description
9.
Manufacturer & product
registration holder
10. Date of revision
1.
WHAT CONDROPIL IS USED FOR
Condropil is used to relieve joint
problems related to osteoarthritis.
2.
HOW CONDROPIL WORKS
Condropil contains glucosamine which
forms a key part of cartilage (the
cushioning substance between bones in
the joints) while chondroitin acts by
preventing damage or breakdown of
cartilage. Glucosamine and chondroitin
act to increase synovial fluid
production, thereby providing lubricant
activity for proper joint function.
3.
BEFORE YOU USE CONDROPIL
_-When you must not use it_

If you are allergic to glucosamine or
chondroitin or any of the ingredients in
the product.

If you are allergic to seafood.

Avoid use during the first 3 months
of pregnancy.
_-Before you start to use it_
Read the instruction and this leaflet
carefully to understand how this
medication should be taken.
Avoid use in children.
Tell your doctor or a pharmacist if you
have any medical conditions,
especially any of the following:

if you are pregnant, planning to
become pregnant, or breastfeeding.

if you have allergies to seafood,
medicines or other substances. This
product contains glucosamine sulphate
and Chondroitin sulphate, seafood-
derived material. It is not
recommended for people with seafood
allergies.

if you have high blood glucose

if you have severe liver and /or
kidney problems
_-Taking other medicines_
Talk to your doctor or a pharmacist if
you are taking:

any medicine for diabetes (to control
the blood sugar), such as metformin,
acarbose, repaglinide.

Warfarin (a blood-thinning drug).
Glucosamine may increase the risk of
bleeding with warfarin and you may
ne

Summary of Product characteristics

CONDROPIL
® CAPSULE
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
Each capsule contains glucosamine sulphate sodium chloride 314 mg
equivalent 250 mg (derived
from seafood) glucosamine sulphate and chondroitin sulphate 200 mg
(derived from fish)
PRODUCT DESCRIPTION
A hard gelatin fish origin capsule, size 0, snap-fit dark blue-white
opaque capsule
with
printed “Condropil” at both sides.
PHARMACODYNAMICS
Glucosamine is a natural substance found in chitin, mucoproteins, and
mucopolysaccharides. It is
involved in the manufacture of glycosaminoglycan, which forms
cartilage tissue in the body;
glucosamine is also present in tendons and ligaments. Glucosamine must
be synthesised by the
body but the ability to do this declines with age. Glucosamine and its
salts have therefore been
advocated in the treatment of rheumatic disorders including
osteoarthritis.
Glucosamine also acts to improve the viscosity of synovial fluid by
increasing synovial fluid
production, thereby providing lubricant activity.
The primary mechanism of action of CS is increased joint
glycosaminologlycan concentration and
a subsequent enhancement of synovial fluid viscosity. Improvement in
joint structure and
function are due to (1) increased endogenous synthesis of hyaluronic
acid and sulfated
glycosamininoglycans from chondroitin sulphate; and (2) reduced break
down of joint
glycosaminoglycans subsequent to decreased collagenolytic activity and
inhibition of enzymes,
such as phospholipase A2 and N-acetylglucosaminidase, which are
capable of degrading existing
joint glycosaminoglycans
Glucosamine and chondroitin work synergistically to stimulate the
anabolic metabolism of osteo-
cartilagineous by stimulating the biosynthesis of the
mucopolysaccharides (which are the
essential components of the cartilage ground substances).
PHARMACOKINETICS
_Absorption_
After oral administration, bioavailability is low due to first-pass
hepatic metabolism~26%. The
gastrointestinal absorption is close to 90%.
In a study of oral chondroitin sulphate in healthy male volu