Country: Malaysia
Language: English
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
SULFAQUINOXALINE
Lim Seng Pharmachem Sdn Bhd
SULFAQUINOXALINE
1000 gm
Thye Pharma Sdn. Bhd
Veterinary Package Insert COCCI 25% W/W PREMIX POWDER (25% Sulfaquinoxaline) PRODUCT DESCRIPTION Pale yellow to yellow colour powder, which contains 250mg of sulfaquinoxaline per gram. PHARMACODYNAMICS & PHARMACOKINETICS Sulfaquinoxaline belongs to a group of antibiotics called the sulphonamides. It is bacteriostatic. Sulfonamides interfere with the biosynthesis of folic acid in bacterial cells; they compete with para- aminobenzoic acid (PABA) for incorporation in the folic acid molecule. By replacing the PABA molecule and preventing the folic acid formation required for DNA synthesis, the sulfonamides prevent multiplication of the bacterial cell. Only organisms that synthesize their own folic acid are susceptible; mammalian cells use preformed folic acid and, therefore, are not susceptible. Cells that produce excess PABA or environments with PABA, such as necrotic tissues, allow for resistance by competition with the sulfonamide. _Absorption _ Most sulfonamides are well absorbed orally with the exception of the enteric sulfonamides, such as sulfaquinoxaline, which are minimally absorbed. Delays in absorption may occur in adult ruminants or when sulfonamides are administered with food to monogastric animals. _Distribution _ Sulfonamides are widely distributed throughout the body. They cross the placenta, and a few penetrate into the cerebrospinal fluid. Sulfonamides may be distributed into milk; however, they vary greatly in their ability to do so. The process depends on several factors, including protein binding and pKa values. _Protein Binding _ Binding can vary depending on serum concentration and other factors. _Biotransformation _ Sulfonamides are primarily metabolized in the liver but metabolism also occurs in other tissues. Biotransformation occurs mainly by acetylation, glucuronide conjugation, and aromatic hydroxylation in many species. The types of metabolites formed and the amount of each varies depending on the specific sulfonamide administered; the species, age, diet, and environment of the animal; t Read the complete document