Citra-Lock S 46.7% catheter lock solution for injection 2.5ml pre-filled syringes

Country: United Kingdom

Language: English

Source: MHRA (Medicines & Healthcare Products Regulatory Agency)

Available from:

Syner-Med (Pharmaceutical Products) Ltd

Class:

No Controlled Drug Status

Prescription type:

Invalid to prescribe in NHS primary care

Product summary:

BNF:

Patient Information leaflet

GB
Catheter-lock
120x2 x 3 ml syringes
COMPOSITION46,7% Trisodium Citrate in water. The Citra-Lock™ is delivered sterile
and supplied as a clear solution. The pH is adjusted to approximately
6,7. Aseptic technique must be maintained at all times. Each single-
use syringe contains 2,5 ml.
PRESCRIPTIONCitra-Lock™ is indicated as a catheter lock solution to prevent coagu-
lation of the blood and infection in any type of intravenous catheter.
To prevent:
• Clotting of blood in catheter
• Bacterial infections in catheter
And reduction of:
• Biofilm formation in catheter
PERFORMANCETrisodium Citrate (TSC) causes anticoagulation by chelation of ionized calcium in the extracorporeal circuit into a soluble complex. Because
calcium is an integral ion involved in the clotting cascade, local remo -
val by citrate prevents the activation of clotting cofactors, factor X, and prothrombin, and the ultimate formation of fibrin. However, systemic
anticoagulation will not occur when the ionized calcium concentration
will be restored. During metabolisation of citrate into bicarbonate, cal -
cium will be released. In this way the level of serum bicarbonate will be maintained.
Antimicrobial effect and a reduction of bioilm formation through bin -
ding and removal of Ca
2+ in the surrounding milieu. Ca 2+ regulates se-
veral genes responsible for growth and multiplying of microbes. Chela-
tion of Mg
2+ results in instability of the cell wall of microbes.
WARNINGS •
Do not use the syringe if the pouch is damaged
• To be used by skilled and trained personnel
• Dispose unused portions
• Citra-Lock™ may not be applied by either direct intravenous injec-
tion or added to an infusion
• Citra-Lock™ is intended only for use as Catheter Lock
• Only inject Citra-Lock™ if the exact catheter volume is known (see
instructions catheter manufacturer)
SIDE-EFFECTS• No side-effects known, when the solution is used as catheter-lock.
• In the event that Citra-Lock™ unintentionally passes into the vein,
paraesthesia and/o