Centrum Kids Strawberry

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

ascorbic acid,Biotin,calcium hydrogen phosphate dihydrate,calcium pantothenate,colecalciferol,cyanocobalamin,dl-alpha-tocopheryl acetate,ferrous fumarate,folic acid,heavy magnesium oxide,manganese sulfate monohydrate,nicotinamide,pyridoxine hydrochloride,retinol palmitate,riboflavine,sodium ascorbate,thiamine nitrate,zinc oxide

Available from:

GlaxoSmithKline Consumer Healthcare Australia Pty Ltd

INN (International Name):

Ascorbic acid,Biotin,calcium hydrogen phosphate dihydrate,colecalciferol,Calcium pantothenate,Cyanocobalamin,dl-alpha-Tocopheryl

Class:

Medicine Listed

Authorization status:

Listed

Patient Information leaflet

ACLIN
_contains the active ingredient sulindac_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Aclin.
It does not contain all of the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Aclin against the
benefits they expect it will have for
you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
Keep this leaflet with your medicine.
You may need to read it again.
WHAT ACLIN IS USED FOR
Aclin relieves pain and reduces
inflammation (swelling, redness and
soreness) that may occur in the
following conditions:
•
various types of arthritis
including osteoarthritis,
rheumatoid arthritis, ankylosing
spondylitis and acute gouty
arthritis
•
muscle and bone injuries such as
sprains, strains, lower back pain
and tendonitis (e.g. tennis elbow).
Aclin belongs to a group of
medicines called Non-Steroidal Anti-
Inflammatory Drugs (NSAIDs).
Your doctor may have prescribed
Aclin for another reason. Ask your
doctor if you have any questions
about why Aclin has been prescribed
for you.
Aclin is available only with a
doctor's prescription.
There is no evidence that Aclin is
addictive.
BEFORE YOU TAKE ACLIN
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE ACLIN IF YOU ARE
ALLERGIC TO MEDICINES CONTAINING
SULINDAC, ASPIRIN, ANY OTHER NSAID
OR ANY OF THE INGREDIENTS LISTED AT
THE END OF THIS LEAFLET.
Some of the symptoms of an allergic
reaction may include skin rash,
itching or hives, swelling of the face,
lips or tongue which may cause
difficulty in swallowing or breathing,
wheezing or shortness of breath.
If you are allergic to aspirin or
NSAIDs and take Aclin, the above
symptoms may be severe.
Many medicines used to treat
headache, period pain and other
aches and pain contain aspirin or
NSAIDs. If you are not sure if you
are taking any of these medicines,
ask your pharmacist.
DO NOT TAKE ACLIN IF:
•
you are vomiting blood

Summary of Product characteristics

PRODUCT INFORMATION
ACLIN
_Sulindac _
NAME OF THE MEDICINE
Active ingredient
:
Sulindac
Chemical name
:
(Z)-5-fluoro-2-methyl-1-[[
_p_
-(methyl-sulfinyl)phenyl]methylene]-1H-indene-3-
acetic acid
Structural formula
:
Sulindac and its metabolites
Molecular formula
:
C
20
H
17
FO
3
S
Molecular weight
:
356.42
CAS Registry no.
:
38194-50-2
DESCRIPTION
Sulindac is a non-steroidal, anti-rheumatic agent with
anti-inflammatory, analgesic and anti-pyretic properties.
It is an arylalkanoic acid derivative but is not a propionic acid. Nor
is it a salicylate, pyrazolone or corticosteroid.
Sulindac
is
a
non-steroidal
anti-inflammatory
indene-type
compound.
Sulindac
is
a
yellow
crystalline
compound. It is a weak organic acid [pKa (25

C) 4.7]. It is soluble in water as the sodium salt or in buffers of
pH 6 or higher but is practically insoluble in water below pH 4.5 and
sparingly soluble in alcohol.
Each Aclin and Aclin 200 tablet contains sulindac 100 mg and 200 mg as
the active ingredient, respectively.
The tablets also contain the following inactive ingredients: lactose
monohydrate, microcrystalline cellulose,
povidone, sodium starch glycollate, quinoline yellow CI47005, purified
talc, magnesium stearate.
PHARMACOLOGY
PHARMACODYNAMICS
Aclin usually provides prompt symptomatic relief of inflammation, pain
and tenderness and promotes early
restoration of joint mobility. The drug has a prolonged duration of
activity which permits a once or twice a day
dosage schedule, and be used for long-term treatment. Sulindac has
been shown to be an effective, well tolerated
compound.
Prostaglandin synthetase inhibition has been hypothesised to be the
basis of the mechanism of action of non-
steroidal
anti-inflammatory
agents
(NSAIDs).
Following
absorption,
sulindac
undergoes
two
major
biotransformations – reversible reduction to the sulphide
metabolite, and irreversible oxidation to the inactive
(SULFONE)
SULINDAC
(SULFOXIDE)
(SULFIDE)
ACLIN - PRODUCT INFORMATION
2
sulfone metabolite. The sulfide metabolite is a potent inhibitor of