Country: Armenia
Language: English
Source: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
carbocisteine
Arpimed LLC
carbocisteine
250mg/5ml
syrup
OTC
SUMMARY PRODUCT CHARACTERISTIC (SPC) CARBOCISTEINE 5 % SYRUP FOR ADULTS TRADE NAME– Carbocisteine 5 % syrup for adults INTERNATIONAL NON-PROPERTY NAME– Carbocisteine COMPOSITION Each 5 ml of Carbocisteine 5% syrup for adults contains: _ACTIVEINGREDIENT:_ carbocisteine-250 mg; _INACTIVE INGREDIENTS:_ sodium saccharin, propylene glycol, _ _sucrose,methylparaben, aroma caramel, sodium hydroxide, color yellow E 110,water deionized ._ _ CHEMICAL NAME AND CAS NUMBER (2R)-2-amino-3-[(carboxymethyl)sulphanyl]propanoic acid , 2387-59-9. PHARMACOLOGICAL GROUP AND ATC CODE Mucolytic agent. ATC code R05CB03. PHARMACOLOGICAL ACTION _Pharmacodynamic properties _ Carbocisteine (S-carboxymethyl L-cysteine) has been shown in normal and bronchitic animal models to affect the nature and amount of mucus glycoprotein which is secreted by the respiratory tract. An increase in the acid:neutral glycoprotein ratio of the mucus and a transformation of serous cells to mucus cells is known to be the initial response to irritation and will normally be followed by hypersecretion. The administration of Carbocisteine to animals exposed to irritants indicates that the glycoprotein that is secreted remains normal; administration after exposure indicates that return to the normal state is accelerated. Studies in humans have demonstrated that Carbocisteine reduces goblet cell hyperplasia. Carbocisteine can therefore be demonstrated to have a role in the management of disorders characterised by abnormal mucus. _Pharmacokinetic properties _ Carbocisteineis rapidly absorbed from the gastrointestinal tract, peak plasma concentrations are reached after about hour(рН 7-9). Bioavailability is low, less than 10% ,probably, due to the metabolism in the gastrointestinal tract and "first pass" through the liver. Carbocisteine is excreted primarily by the kidneys. The half-life is about 2 hours. USES Violations of bronchial secretions (including acute bronchitis and acute exacerbations of chronic diseases of the bronchi and lungs). DOSAGEANDADMINISTRATIO Read the complete document