BRUFEN 600 TABLET 600 mg
Country: Singapore
Language: English
Source: HSA (Health Sciences Authority)
Patient Information leaflet
(PIL)
28-01-2014
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Active ingredient:
Ibuprofen
Available from:
ABBOTT LABORATORIES (SINGAPORE ) PRIVATE LIMITED
ATC code:
M01AE01
Dosage:
600 mg
Pharmaceutical form:
TABLET, FILM COATED
Administration route:
ORAL
Prescription type:
Prescription Only
Manufactured by:
PT. Abbott Indonesia
Authorization date:
1991-04-08
Patient Information leaflet
BRUFEN
®
600
Ibuprofen 600mg
Analgesic & Anti-inflammatory Agent
Ibuprofen is a member of the propionic acid group of nonsteroidal
anti-inflammatory
drugs (NSAIDs). Brufen
®
600 is a racemic mixture of [+]S- and [-]R-enantiomers.
Brufen
®
600 has shown anti-inflammatory, analgesic and antipyretic activity
in both
animal and human studies. These properties provide symptomatic
relief of inflammation
and painful.
It is a colorless crystalline stable solid, with a melting point of
75° to 77°C. It is relatively
insoluble in water but readily soluble in most organic solvents.
Ibuprofen has a pKa of
4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH
7.4.
The chemical name for Ibuprofen is (±)-2-(4-isobutylphenyl) propionic
acid. The
molecular weight of Ibuprofen is 206.28 and its molecular formula is C
13
H
18
O
2
.
INDICATIONS
Brufen
®
600 is indicated for its anti-inflammatory and analgesic
effect in the treatment of
rheumatoid arthritis, osteoarthritis and allied conditions,
non-articular rheumatism and
soft tissue injuries. Brufen
®
600 is also indicated for its analgesic effect in the relief of
mild to moderate pain such as dysmenorrhoea, dental
pain, post-operative pain and in
the relief of migraine headache. Its antipyretic activity is
effective in reducing fever.
DOSAGE & ADMINISTRATION
ADULTS
The recommended initial dosage is 1200mg – 1800mg daily in divided
doses. Some
patients can be maintained on 600 – 1200mg daily. The total daily
dose of Brufen
®
600
should not exceed 2400mg.
CHILDREN
The recommended dose of Brufen
®
600 is 20mg/kg of body weight daily in divided
doses, but in juvenile rheumatoid arthritis the dosage may
be increased to 40mg/kg body
weight daily in divided doses, in severe cases. Not recommended for
children weighing
less than 7kg.
ELDERLY
No special dosage modifications are required for elderly patients
unless renal or hepatic
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