AVICOL (FLORFENICOL 15% WV ORAL SOLUTION)

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

FLORFENICOL

Available from:

Fijiliam Enterprise Sdn. Bhd.

INN (International Name):

FLORFENICOL

Units in package:

1 L

Manufactured by:

Nam Pharma Sdn. Bhd.

Summary of Product characteristics

AVICOL (FLORFENICOL 15% W/V ORAL SOLUTION)
CONTROLLED MEDICINE
Composition:
Each 1L contains:
Florfenicol……150 gm
Product description:
Solution for use in Drinking Water.
Clear, colourless to yellow solution.
Target species:
Poultry ( Chicken ) and Swine ( pig )
Pharmacokinetics
Swine:
After administration to pigs by gavage at 15 mg/kg under experimental
conditions,
Florfenicol was detectable in the serum of all animals through 12
hours after gavage. After gavage
of florfenicol on the fifth day, the maximum serum florfenicol
concentrations were between 2.78
µg/ml and 7.34 µg/ml and the median terminal half life was 2.0
hours. The extent of bioavailability
ranged from 24% to 97%.
Poultry:
Serum concentrations versus time in chickens after the administration
of florfenicol in drinking
water at an expected concentration of 100 ppm for 18 hours per day
over 3 days.
Pharmacodynamics
Swine:
Florfenicol is a synthetic broad spectrum antibiotic active against
many gram-negative and gram-
positive bacteria isolated from domestic animals. It acts by
inhibiting bacterial protein synthesis.In
vivo activity has been demonstrated against bacterial pathogens
commonly associated with swine
respiratory disease,including Actinobacillus pleuropneumoniae and
Pasteurella multocida
Poultry :
Florfenicol is a synthetic broad spectrum antibiotic active against
many gram-negative and gram-
positive bacteria isolated from domestic animals. It acts by
inhibiting bacterial protein synthesis.
Indication:
Treatment of bacterial diseases suspectible to florfenicol.
Chicken:
Effective against species: E.Coli
Indication: Colibacillosis
Pig:
Effective against species: Actinobacillus pleuropneumoniae,
Pasteurella multocida,
Streptococcus suis, Mycoplasma Hyopneumoniae
Indication: Pleuropneumonia, Pneumonic pasteurellosis, Streptococcal
infection,
Mycoplasma pneumonia
Dosage and Administration
Oral administration through drinking water.
Chicken:
0.13 ml (equivalent to 20 mg florfenicol) per kg body weight for 5
days.
Pig:
0.067 ml (equivalent