Country: United States
Language: English
Source: NLM (National Library of Medicine)
ISOFLURANE (UNII: CYS9AKD70P) (ISOFLURANE - UNII:CYS9AKD70P)
Piramal Critical Care Inc
ISOFLURANE
ISOFLURANE 1 mL in 1 mL
RESPIRATORY (INHALATION)
PRESCRIPTION
Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs. Isoflurane is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.
Attane (isoflurane, USP) is packaged in 100 mL and 250 mL amber-colored bottles. 100 ML - NDC 66794-014-10 250 ML - NDC 66794-014-25
Abbreviated New Animal Drug Application
ATTANE - ISOFLURANE LIQUID PIRAMAL CRITICAL CARE INC ---------- ATTANE™ ISOFLURANE, USP INHALATION ANESTHETIC FOR VETERINARY USE IN HORSES AND DOGS WARNING: NOT FOR USE IN HORSES INTENDED FOR FOOD. CAUTION Federal Law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Isoflurane, USP, a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is l-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is: Each mL contains 99.9% isoflurane. Some physical constants are: Molecular weight 184.5 Boiling point at 760 mm Hg 48.5°C (uncorr.) Refractive index n D 1.2990-1.3005 Specific gravity 25° /25° C 1.496 Vapor pressure in mm Hg** 20° C 238 20 25° C 295 30° C 367 35° C 450 **Equation for vapor pressure calculation: A = 8.056 log _P_ = A + B B = -1664.58 T T = C + 273.16 Partition coefficients at 37°C: Water/gas 0.61 Blood/gas 1.43 Oil/gas 90.8 Partition coefficients at 25°C - rubber and plastic Conductive rubber/gas 62.0 Butyl rubber/gas 75.0 Polyvinyl chloride/gas 110.0 Polyethylene/gas ~2.0 Polyurethane/gas ~1.4 Polyolefin/gas ~1.1 Butyl acetate/gas ~2.5 Purity by gas chromatography >99.9% Lower limit of flammability in oxygen or None nitrous oxide at 9 joules/sec. and 23° C Lower limit of flammability in oxygen or Greater than useful nitrous oxide at 900 joules/sec. and 23° C concentration in anesthesia. MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in dogs. Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in 10 vap o 1 6 indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2-amp, 115-volt, 60-cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indi Read the complete document