APO-Prochlorperazine

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Prochlorperazine maleate

Available from:

Apotex Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

APO-
PROCHLORPERAZINE

_Contains the active ingredient, prochlorperazine (as maleate)_
CONSUMER MEDICINE INFORMATION

_FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
ASK YOUR DOCTOR OR PHARMACIST IF
YOU DO NOT UNDERSTAND ANYTHING OR
ARE WORRIED ABOUT TAKING YOUR
MEDICINE.
This leaflet answers some common
questions about prochlorperazine.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
your medicine may be available.
Speak to your pharmacist or doctor to
obtain the most up-to-date
information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may want to read it again.
WHAT
PROCHLORPERAZINE IS
USED FOR
The name of your medicine is APO-
Prochlorperazine. It contains the
active ingredient, prochlorperazine
(as prochlorperazine maleate).
Prochlorperazine belongs to a group
of medicines called phenothiazines.
It helps to correct chemical
imbalances in the brain, allowing it
to function correctly. These
chemicals may also affect the parts of
the brain which control nausea
(feeling sick) and vomiting.
It is used to treat nausea, vomiting
and dizziness due to various causes,
including migraine (severe
headache).
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you.
Your doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_USE IN CHILDREN_
Prochlorperazine is not
recommended for use in children
(under the age of 2 years or children
under 10 kg in weight).
BEFORE YOU TAKE
PROCHLORPERAZINE
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE THIS MEDICINE IF YOU
HAVE IN THE PAST EXPERIENCED
JAUNDIC

Summary of Product characteristics

_                                        

                           _Product Information 
– Australia 

APO-Prochlorperazine Tablets

Page 1 of 8 
APO-PROCHLORPERAZINE TABLETS 

NAME OF THE MEDICINE 

NON-PROPRIETARY NAME:  
Prochlorperazine maleate 
CHEMICAL NAME: 
2 chloro-10-(3-(4-methyl piperazinyl)-propyl) phenothiazine 
MOLECULAR WEIGHT: 

606.2 
MOLECULAR FORMULA: 
C
20
H
24
CIN
3
S.2C
4
H
4
O
4

CAS NUMBER: 
84-02-6 
STRUCTURAL FORMULA: 

DESCRIPTION 

Prochlorperazine  maleate  contains  62%  of  the  active  base  prochlorperazine.  It  is  an  odourless, 
nonhydroscopic,  white or  almost  white,  fine  granular  powder,  which  becomes  coloured  on  exposure 
to light. It is sparingly soluble (about 0.1%) in water, ethanol or methanol and is insoluble in ether or 
chloroform. 

PHARMACOLOGY 

Prochlorperazine  is  a  phenothiazine  with  a  piperazine  moiety  in  the  side  chain.  It  possesses  strong 
antiemetic and antipsychotic activity with less sedative action than
chlorpromazine. 

PHARMACODYNAMICS 
As with other phenothiazines, prochlorperazine has actions on
several neurotransmitter systems: 
1.  Antidopamine action, which probably contributes to both the therapeutic effect and unwanted 
effects including
extrapyramidal disorders and endocrine disturbances. 
2. 
α-Adrenoreceptor  antagonism,  which  contributes  to  cardiovascular  side  effects  such  as 
orthostatic hypotension and reflex tachycardia. 
3.  Potentiation of noradrenaline by blocking its reuptake
into nerve terminals. 
4.  Weak anticholinergic action. 
5.  Weak antihistamine action. 
6.  Weak serotonin antagonism. 

Prochlorperazine  also  has  an