APO-Frusemide

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Frusemide

Available from:

Apotex Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

APO-FRUSEMIDE

_Contains the active ingredient frusemide_
CONSUMER MEDICINE INFORMATION

_FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about frusemide. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is APO-
Frusemide. It contains the active
ingredient frusemide.
Frusemide belongs to a family of
drugs called diuretics. A diuretic
helps reduce the amount of excess
fluid in the body by increasing the
amount of urine produced.
Frusemide is used to treat swelling of
the ankles, feet, legs or even the
brain or lungs. This swelling is called
oedema and can occur in some heart,
lung, liver or kidney conditions.
Frusemide may be used in some
patients with more serious kidney
problems who may have some fluid
retention.
Frusemide may also be used to lower
high blood pressure (which is also
called hypertension).
Everyone has blood pressure. This
pressure helps move your blood
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
ar

Summary of Product characteristics

Product Information 
– Australia 
APO-Frusemide tablets 
Page 1 
APO-FRUSEMIDE TABLETS 

NAME OF THE MEDICINE 
Frusemide. 

Chemical Name: 
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid 

Structural Formula: 

Molecular Formula: 
C
12
H
11
ClN
2
O
5
S 

Molecular Weight: 
330.744 

CAS Registry Number:  54-31-9 

DESCRIPTION 
Frusemide is an anthranilic acid derivative.  It is a white to off-white odourless crystalline powder.  It is 
practically  insoluble  in  water,  sparingly  soluble  in  alcohol,  freely  soluble  in  dilute  alkali  solutions  and 
insoluble in dilute acids. 

Frusemide  tablets  are  intended  for  oral  administration.    Each  tablet  contains  20  mg  or  40  mg 
frusemide.  In addition, each tablet contains the following inactive ingredients: lactose, maize starch, 
pregelatinised maize starch, sodium starch glycollate (type A)
and magnesium stearate. 

PHARMACOLOGY 
PHARMACODYNAMICS 
Frusemide  is  a  potent  diuretic.    It  inhibits  sodium  and  chloride  absorption  in  the  ascending  limb  of 
Henle's  loop  and  in  both  the  proximal  and  distal  tubules.    The  high  degree  of  efficacy  is  due  to  this 
unique site of action.  The action on the
distal tubule is independent of any inhibitory effect on carbonic 
anhydrase or aldosterone. 

Frusemide may promote diuresis in cases which have previously
proved resistant to other diuretics. 

Frusemide has no significant pharmacological effects other than
on renal function. 

PHARMACOKINETICS 
Absorption: 
Frusemide  is  rapidly  absorbed  from  the  gastrointestinal  tract.    Absorption  rates  in  healthy  subjects 
have been reported from 60
–69% and from 43–46% in patients with end stage renal
failure.