AMYL NITRITE inhalant

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

AMYL NITRITE (UNII: 22T8Z09XAK) (Amyl Nitrite - UNII:22T8Z09XAK)

Available from:

James Alexander Corporation

Administration route:

RESPIRATORY (INHALATION)

Prescription type:

PRESCRIPTION DRUG

Therapeutic indications:

Amyl nitrite is indicated for the rapid relief of angina pectoris. Its effect appears within 30 seconds and lasts for approximately 3 to 5 minutes. Since it may increase intraocular and intracranial pressures, amyl nitrite is contraindicated or should be used with great caution in patients with glaucoma, recent head trauma or cerebral hemorrhage. Amyl nitrite can cause harm to the fetus when it is administered to a pregnant woman because it significantly reduces systemic blood pressure and blood flow on the maternal side of the placenta. Abuse - Volatile nitrites are abused for sexual stimulation, with headache as a common side effect. Dependence - Tolerance to nitrites can develop; conditions and duration have not been established.

Product summary:

JAMES ALEXANDER brand amyl nitrite is furnished in covered glass capsules. Each capsule contains 0.3 mL in boxes of 12.  Capsule contents are FLAMMABLE and should be protected from light. Storage should be in a cold place. 2o - 8o C (36o - 46o F) The James Alexander Corporation Blairstown, New Jersey 07825. Rev. 03                            July 2012 Rx only.

Authorization status:

unapproved drug other

Summary of Product characteristics

AMYL NITRITE- AMYL NITRITE INHALANT
JAMES ALEXANDER CORPORATION
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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AMYL NITRITE INHALANTS USP
AMYL NITRITE INHALANT, USP
DESCRIPTION:
Amyl nitrite is a rapidly acting vasodilator administered by
inhalation. 0.3mL is supplied in a covered
thin glass capsule which is easily crushed between the fingers. Amyl
nitrite is a clear, yellowish liquid
having a peculiar ethereal, fruity odor. It is volatile, even at low
temperatures, and is flammable. This
product is stabilized with Linseed Oil Epoxy. The structural formula
of amyl nitrite is:
(CH )
CHCH
CH
ONO
CLINICAL PHARMACOLOGY:
Amyl nitrite causes a non specific relaxation of smooth muscle with
the most prominent actions
occurring in vascular smooth muscle. This effect on vascular smooth
muscle results in coronary
vasodilation and decreased systemic vascular resistance and left
ventricular preload and afterload.
Myocardial ischemia is relieved in patients with angina pectoris, with
an abatement of chest pain and
possibly other related symptoms. Amyl nitrite vapors are absorbed
rapidly through the pulmonary
alveoli, manifesting therapeutic effects within one minute after
inhalation. The drug is metabolized
rapidly, probably by hydrolytic denitration; approximately one-third
of the inhaled amyl nitrite is
excreted in the urine.
INDICATIONS AND USAGE:
Amyl nitrite is indicated for the rapid relief of angina pectoris. Its
effect appears within 30 seconds and
lasts for approximately 3 to 5 minutes.
CONTRAINDICATIONS:
Since it may increase intraocular and intracranial pressures, amyl
nitrite is contraindicated or should be
used with great caution in patients with glaucoma, recent head trauma
or cerebral hemorrhage.
Amyl nitrite can cause harm to the fetus when it is administered to a
pregnant woman because it
significantly reduces systemic blood pressure and blood flow on the
materna