VERAPAMIL HYDROCHLORIDE tablet

Χώρα: Ηνωμένες Πολιτείες

Γλώσσα: Αγγλικά

Πηγή: NLM (National Library of Medicine)

Δραστική ουσία:

VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)

Διαθέσιμο από:

REMEDYREPACK INC.

Οδός χορήγησης:

ORAL

Τρόπος διάθεσης:

PRESCRIPTION DRUG

Θεραπευτικές ενδείξεις:

Verapamil hydrochloride tablets, USP are indicated for the treatment of the following: 1.  Angina at rest including: -  Vasospastic (Prinzmetal's variant) angina -  Unstable (crescendo, pre-infarction) angina 2. Chronic stable angina (classic effort-associated angina) - In association with digitalis for the control of ventricular rate at rest and during stress in patients with chronic atrial flutter and/or atrial fibrillation (see WARNINGS: Accessory bypass tract) - Prophylaxis of repetitive paroxysmal supraventricular tachycardia Verapamil hydrochloride is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including this drug. Control of high blood pressure should be part of comprehensive cardiovascular risk management, i

Περίληψη προϊόντος:

Verapamil Hydrochloride Tablets, USP 120 mg tablets are round, standard concave, white film-coated, scored, debossed "HP" above and "27" below on one side and plain on the reverse side, supplied as: NDC: 70518-1464-00 PACKAGING: 30 in 1 BLISTER PACK Store at 20° to 25°C (68° to 77°F) [See USP controlled room temperature] and protect from light. Dispense in a tight, light-resistant container using a child-resistant closure. Repackaged and Distributed By: Remedy Repack, Inc. 625 Kolter Dr. Suite #4 Indiana, PA 1-724-465-8762

Καθεστώς αδειοδότησης:

Abbreviated New Drug Application

Αρχείο Π.Χ.Π.

VERAPAMIL HYDROCHLORIDE- VERAPAMIL HYDROCHLORIDE TABLET
REMEDYREPACK INC.
----------
VERAPAMIL HYDROCHLORIDE TABLETS, USP
RX ONLY
DESCRIPTION
Verapamil hydrochloride (verapamil HCl) tablets, USP is a calcium ion
influx inhibitor
(slow-channel blocker or calcium ion antagonist) available for oral
administration in film-
coated tablets containing 40 mg, 80 mg or 120 mg of verapamil
hydrochloride.
The structural formula of verapamil HCl is:
C
H
N
O
• HCl M.W. =
491.08
Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]
methylamino]propyl]-3,4-
dimethoxy-α-(1-methylethyl) hydrochloride
Verapamil HCl is an almost white, crystalline powder, practically free
of odor, with a bitter
taste. It is soluble in water, chloroform, and methanol. Verapamil HCl
is not chemically
related to other cardioactive drugs.
Inactive ingredients include colloidal silicon dioxide, dibasic
calcium phosphate dihydrate,
magnesium stearate, microcrystalline cellulose, sodium starch
glycolate, light mineral oil,
sodium lauryl sulfate, titanium dioxide and hypromellose.
CLINICAL PHARMACOLOGY
Verapamil hydrochloride is a calcium ion influx inhibitor
(slow-channel blocker or calcium
ion antagonist) that exerts its pharmacologic effects by modulating
the influx of ionic
calcium across the cell membrane of the arterial smooth muscle as well
as in conductile
and contractile myocardial cells.
MECHANISM OF ACTION
ANGINA: The precise mechanism of action of verapamil hydrochloride as
an antianginal
agent remains to be fully determined, but includes the following two
mechanisms:
1. _ Relaxation and prevention of coronary artery spasm:_ Verapamil
hydrochloride dilates
the main coronary arteries and coronary arterioles, both in normal and
ischemic
regions, and is a potent inhibitor of coronary artery spasm, whether
spontaneous or
27
38
2
4
ergonovine-induced. This property increases myocardial oxygen delivery
in patients
with coronary artery spasm and is responsible for the effectiveness of
verapamil
hydrochloride in vasospastic (Prinzmetal's or var