POTASSIUM CHLORIDE tablet, extended release

Χώρα: Ηνωμένες Πολιτείες

Γλώσσα: Αγγλικά

Πηγή: NLM (National Library of Medicine)

Δραστική ουσία:

POTASSIUM CHLORIDE (UNII: 660YQ98I10) (POTASSIUM CATION - UNII:295O53K152)

Διαθέσιμο από:

McKesson Packaging Services Business Unit of McKesson Corporation

INN (Διεθνής Όνομα):

POTASSIUM CHLORIDE

Σύνθεση:

POTASSIUM CHLORIDE 750 mg

Οδός χορήγησης:

ORAL

Τρόπος διάθεσης:

PRESCRIPTION DRUG

Θεραπευτικές ενδείξεις:

BECAUSE OF REPORTS OF INTESTINAL AND GASTRIC ULCERATION AND BLEEDING WITH EXTENDED-RELEASE POTASSIUM CHLORIDE PREPARATIONS, THESE DRUGS SHOULD BE RESERVED FOR THOSE PATIENTS WHO CANNOT TOLERATE OR REFUSE TO TAKE LIQUID OR EFFERVESCENT POTASSIUM PREPARATIONS OR FOR PATIENTS IN WHOM THERE IS A PROBLEM OF COMPLIANCE WITH THESE PREPARATIONS. The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated. Potassium supplements are contraindicated in patients with hyperkalemia since a further increase in serum potassium concentration in such pat

Περίληψη προϊόντος:

Potassium Chloride Extended-release Tablet, USP, 1500 mg of potassium chloride (20 mEq of potassium) are available in: Potassium Chloride Extended-release Tablets, USP 20 mEq are white, oblong, imprinted US 20 and scored for flexibility of dosing. Potassium Chloride Extended-release Tablet, USP, 750 mg of potassium chloride (10 mEq of potassium) are available in: Potassium Chloride Extended-release Tablets, USP 10 mEq are white, oblong imprinted US 10.

Καθεστώς αδειοδότησης:

Abbreviated New Drug Application

Αρχείο Π.Χ.Π.

POTASSIUM CHLORIDE- POTASSIUM CHLORIDE TABLET, EXTENDED RELEASE
MCKESSON PACKAGING SERVICES BUSINESS UNIT OF MCKESSON CORPORATION
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POTASSIUM CHLORIDE EXTENDED-RELEASE TABLETS, USP MICROENCAPSULATED
DESCRIPTION
Potassium Chloride Extended-release Tablets, USP are an immediately
dispersing extended-release
oral dosage form of potassium chloride containing 1500 mg of
microencapsulated potassium chloride,
USP equivalent to 20 mEq of potassium in a tablet.
Potassium Chloride Extended-release Tablets, USP are an immediately
dispersing extended-release
oral dosage form of potassium chloride containing 750 mg of
microencapsulated potassium chloride,
USP equivalent to 10 mEq of potassium in a tablet.
These formulations are intended to slow the release of potassium so
that the likelihood of a high
localized concentration of potassium chloride within the
gastrointestinal tract is reduced.
Potassium Chloride Extended-release Tablets, USP is an electrolyte
replenisher. The chemical name of
the active ingredient is potassium chloride, and the structural
formula is KCl (molecular weight: 74.55).
Potassium Chloride, USP occurs as a white, granular powder or as
colorless crystals. It is odorless and
has a saline taste. Its solutions are neutral to litmus. It is freely
soluble in water and insoluble in alcohol.
Potassium Chloride Extended-release Tablets, USP is a tablet
formulation (not enteric coated or wax
matrix) containing individually microencapsulated potassium chloride
crystals which disperse upon
tablet disintegration. In simulated gastric fluid at 37°C and in the
absence of outside agitation, Potassium
Chloride Extended-release Tablets, USP begins disintegrating into
microencapsulated crystals within
seconds and completely disintegrates within one minute. The
microencapsulated crystals are formulated
to provide an extended release of potassium chloride.
Inactive Ingredients: croscamellose sodium, ethylcellulose and
microcrystalline cellulose.
CLINICAL PHARMACOLOGY
The potassium ion is the principal intracellul