FLEXPROFEN- carprofen tablet, chewable

Χώρα: Ηνωμένες Πολιτείες

Γλώσσα: Αγγλικά

Πηγή: NLM (National Library of Medicine)

Δραστική ουσία:

carprofen (UNII: FFL0D546HO) (carprofen - UNII:FFL0D546HO)

Διαθέσιμο από:

Vetoquinol USA Inc

Οδός χορήγησης:

ORAL

Τρόπος διάθεσης:

PRESCRIPTION

Θεραπευτικές ενδείξεις:

INDICATIONS: Flexprofen is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. CONTRAINDICATIONS: Flexprofen should not be used in dogs exhibiting previous hypersensitivity to carprofen.

Περίληψη προϊόντος:

HOW SUPPLIED: Flexprofen chewable tablets are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per tablet. Each tablet size is packaged in bottles containing 180 tablets.

Καθεστώς αδειοδότησης:

Abbreviated New Animal Drug Application

Αρχείο Π.Χ.Π.

FLEXPROFEN- CARPROFEN TABLET, CHEWABLE
VETOQUINOL USA INC
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FLEXPROFEN™
(CARPROFEN)
CHEWABLE TABLETS
_NON-STEROIDAL, ANTI-INFLAMMATORY DRUG_
FOR ORAL USE IN DOGS ONLY
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed veterinarian.
DESCRIPTION: Flexprofen (carprofen) is a non-steroidal
anti-inflammatory drug (NSAID) of the
propionic acid class that includes ibuprofen, naproxen, and
ketoprofen. Carprofen is the nonproprietary
designation for a substituted carbazole,
6-Chloro-α-methyl-9H-carbazole-2-acetic acid. The empirical
formula is C
H CINO and the molecular weight 273.72. The chemical structure of
carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically insoluble in
water at 25°C.
CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal
anti-inflammatory agent
with characteristic analgesic and antipyretic activity approximately
equipotent to indomethacin in animal
models.
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be associated with the
inhibition of cyclooxygenase activity. Two unique cyclooxygenases have
been described in mammals.
The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins
necessary for normal
gastrointestinal and renal function. The inducible cyclooxygenase,
COX-2, generates prostaglandins
involved in inflammation. Inhibition of COX-1 is thought to be
associated with gastrointestinal and renal
toxicity while inhibition of COX-2 provides anti-inflammatory
activity. The specificity of a particular
NSAID for COX-2 versus COX-1 may vary from species to species.
In an _in vitro_ study using canine
cell cultures, carprofen demonstrated selective inhibition of COX-2
versus COX-1.
Clinical relevance
of these data has not been shown. Carprofen has also been shown to
inhibit the release of several
prostaglandins in two inflammatory cell systems: rat polymorphonuclear
leukocytes (PMN) and human
rheumatoid synovial cells, indicating inhibition of acute (PMN