Dizole

Χώρα: Αυστραλία

Γλώσσα: Αγγλικά

Πηγή: Department of Health (Therapeutic Goods Administration)

Δραστική ουσία:

Fluconazole

Διαθέσιμο από:

Alphapharm Pty Ltd

Kατηγορία:

Medicine Registered

Φύλλο οδηγιών χρήσης

DIZOLE

_contains the active ingredient fluconazole_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Dizole.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Dizole against the
benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT DIZOLE IS USED
FOR
Dizole capsules containing
fluconazole as the active ingredient
are used to treat certain fungal and
yeast infections that cause:
•
thrush in the mouth, food pipe or
vagina (also called candida or
monilia)
•
tinea of the body, groin or feet
•
meningitis, where the membrane
around the brain and spinal cord
are inflamed due to infection.
Fluconazole belongs to a group of
medicines called azole antibiotics.
It works by preventing the growth of
the fungal and yeasts organisms
causing your infection.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
Dizole is available only with a
doctor's prescription.
This medicine is not addictive.
BEFORE YOU TAKE DIZOLE
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE DIZOLE IF YOU HAVE AN
ALLERGY TO:
•
any medicine containing
fluconazole
•
any other azole antifungals
related to fluconazole such as
itraconazole (Sporanox),
ketoconazole (Nizoral),
miconazole (Daktarin),
clotrimazole (Canesten).
•
any of the ingredients listed at the
end of this leaflet.
Some of the symptoms of an allergic
reaction may include:
•
shortness of breath
•
wheezing or difficulty breathing
•
swelling of the face, lips, tongue
or other parts of the body
•
rash, itching or hives on the skin.
DO NOT TAKE DIZOLE IF YOU ARE
TAKING CISAPRIDE (PREPULSID), A
MEDICINE USED TO TREAT STOMACH
PROBLEMS.
DO NO

Αρχείο Π.Χ.Π.

DIZOLE 
_Fluconazole _

PRODUCT INFORMATION 
NAME OF THE MEDICINE 
Active ingredient: 
Fluconazole 
Chemical name:  
2-(2,4-difluorophenyl)-1,3-bis (1H-1, 2,4-triazol-1-yl)-2-propanol 
Structural formula: 

Molecular formula: 
C
13
H
12
F
2
N
6
O  

Molecular weight: 
306.3. 

CAS Registry no.: 
86386-73-4 
DESCRIPTION 
Fluconazole is a white
to off-white crystalline powder, which is sparingly soluble in
water and saline.   
DIZOLE is available as gelatin capsules containing 50 mg,
100 mg, 150 mg or 200 mg fluconazole.  
Other ingredients - gelatin, lactose, starch-maize, silicon dioxide, magnesium stearate, sodium lauryl sulfate, 
titanium dioxide, TekPrint SW-9008 black printing ink,
TekPrint SW-9009 black printing ink, patent blue V 
CI42051 (50, 100 and 200 mg capsules only),
brilliant scarlet 4R CI16255 (50 mg capsules only). 
PHARMACOLOGY 
PHARMACODYNAMICS 
Fluconazole is a member of the bis-triazole class
of antifungal agents.  Fluconazole is a highly selective 
inhibitor of fungal cytochrome P-450 sterol C-14
alpha-demethylation.  Mammalian cell demethylation is 
much less sensitive to fluconazole inhibition. 
The subsequent loss of normal sterols correlates with the 
accumulation of 14 alpha-methyl sterols in fungi and may be
responsible for the fungistatic activity of 
fluconazole. Fluconazole 50 mg daily given for up to 28
days has been shown not to affect corticosteroid 

N 
N 
N 
N 
N 
N 
F 
F 
OH 
DIZOLE – Product Information 
2 

levels or adrenocorticotrophic hormone (ACTH) stimulated response
in healthy female volunteers.  Plasma 
oestradiol levels and urinary free cortisol levels were
decreased with little effect on plasma testosterone 
levels. Interaction studies with antipyrine indicate that single or multiple doses of fluconazole 50 mg do not 
affect�