DIPHENHYDRAMINE HYDROCHLORIDE injection solution

Χώρα: Ηνωμένες Πολιτείες

Γλώσσα: Αγγλικά

Πηγή: NLM (National Library of Medicine)

Δραστική ουσία:

DIPHENHYDRAMINE HYDROCHLORIDE (UNII: TC2D6JAD40) (DIPHENHYDRAMINE - UNII:8GTS82S83M)

Διαθέσιμο από:

Cardinal Health

INN (Διεθνής Όνομα):

DIPHENHYDRAMINE HYDROCHLORIDE

Σύνθεση:

DIPHENHYDRAMINE HYDROCHLORIDE 50 mg in 1 mL

Τρόπος διάθεσης:

PRESCRIPTION DRUG

Καθεστώς αδειοδότησης:

Abbreviated New Drug Application

Αρχείο Π.Χ.Π.

DIPHENHYDRAMINE HYDROCHLORIDE- DIPHENHYDRAMINE HYDROCHLORIDE
INJECTION,
SOLUTION
CARDINAL HEALTH
----------
DIPHENHYDRAMINE
HYDROCHLORIDE INJECTION, USP
R only
DESCRIPTION
Diphenhydramine hydrochloride is an antihistamine drug having the
chemical name
2 (Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride. It occurs as
a white, crystalline powder,
is freely soluble in water and alcohol and has a molecular weight of
291.82. The molecular formula is
C
H NO • HCl and the structural formula is as follows:
Diphenhydramine hydrochloride in the parenteral form is a sterile,
pyrogen-free solution available in a
concentration of 50 mg of diphenhydramine hydrochloride per mL for
intramuscular or intravenous use.
The solution for parenteral use has been adjusted to a pH between 4
and 6.5 with either sodium
hydroxide or hydrochloric acid.
CLINICAL PHARMACOLOGY
Diphenhydramine hydrochloride is an antihistamine with anticholinergic
(drying) and sedative side
effects. Antihistamines appear to compete with histamine for cell
receptor sites on effector cells.
Diphenhydramine hydrochloride in the injectable form has a rapid onset
of action. Diphenhydramine
hydrochloride is widely distributed throughout the body, including the
CNS. A portion of the drug is
excreted unchanged in the urine, while the rest is metabolized via the
liver. Detailed information on the
pharmacokinetics of Diphenhydramine Hydrochloride Injection is not
available.
INDICATIONS AND USAGE
Diphenhydramine hydrochloride in the injectable form is effective in
adults and pediatric patients, other
than premature infants and neonates, for the following conditions when
diphenhydramine hydrochloride
in the oral form is impractical.
_Antihistaminic:_ For amelioration of allergic reactions to blood or
plasma, in anaphylaxis as an adjunct to
epinephrine and other standard measures after the acute symptoms have
been controlled, and for other
uncomplicated allergic conditions of the immediate type when oral
therapy is impossible or
contraindicated.
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