CLONIDINE TABLET

Χώρα: Καναδάς

Γλώσσα: Αγγλικά

Πηγή: Health Canada

Δραστική ουσία:

CLONIDINE HYDROCHLORIDE

Διαθέσιμο από:

SANIS HEALTH INC

Φαρμακολογική κατηγορία (ATC):

C02AC01

INN (Διεθνής Όνομα):

CLONIDINE

Δοσολογία:

0.1MG

Φαρμακοτεχνική μορφή:

TABLET

Σύνθεση:

CLONIDINE HYDROCHLORIDE 0.1MG

Οδός χορήγησης:

ORAL

Μονάδες σε πακέτο:

100/500

Τρόπος διάθεσης:

Prescription

Θεραπευτική περιοχή:

CENTRAL ALPHA-AGONISTS

Περίληψη προϊόντος:

Active ingredient group (AIG) number: 0108891001; AHFS:

Καθεστώς αδειοδότησης:

CANCELLED POST MARKET

Ημερομηνία της άδειας:

2012-08-03

Αρχείο Π.Χ.Π.

PRODUCT MONOGRAPH
Pr
CLONIDINE
(Clonidine Hydrochloride)
0.1 and 0.2 mg Tablets
USP
Antihypertensive
Sanis Health Inc.
333 Champlain Street, Suite 102
Dieppe, New Brunswick
Canada, E1A 1P2
Submission Control No: 143935
Date of Preparation:
January 6, 2011
PRODUCT MONOGRAPH
CLONIDINE
(Clonidine Hydrochloride)
0.1 and 0.2 mg Tablets
USP
THERAPEUTIC CLASSIFICATION
Antihypertensive Agent
ACTION AND CLINICAL PHARMACOLOGY
Clinically, the principal effects seen with CLONIDINE (clonidine
hydrochloride) are consistent
with a direct action of the drug on the vasomotor centres in the brain
stem. There is no blockade
of peripheral ganglia, neurons or receptors. In animals, following
clonidine administration,
spontaneous sympathetic discharges from the medullary centres are
reduced. A lowered tone of
the vasomotor centres rather than blockade is suggested by the
differential action on spontaneous
and evoked central sympathetic impulses. Thus, clonidine has the
ability to lower blood pressure
while preserving normal homeostatic mechanisms.
A pressor phase is not seen if the drug is given intramuscularly or
orally, although with
intravenous use of the drug a transient rise in blood pressure may
precede the prolonged period
of hypotension. The pressor phase following intravenous clonidine has
been shown to be due to a
direct effect of the drug on peripheral α-receptors, and this phase
of the blood pressure effect and
the depressor phase can be reversed by α-blocking drugs. It has been
suggested therefore, that
clonidine exerts an action on postulated central α-receptors in a
manner similar to the action in
the periphery. The prolonged hypotensive phase may thus result from
two opposing actions each
mediated by α-receptors.
Effects on Catecholamines, Renin and Aldosterone:
Tissue stores of catecholamines are not depleted by clonidine.
However, as would be expected
with central depression of sympathomimetic activity, clonidine therapy
results in diminished
urinary excretion of catecholamines. Conversely, there may be a sharp
i