Ramipril-GA

Land: Australien

Sprache: Englisch

Quelle: Department of Health (Therapeutic Goods Administration)

Wirkstoff:

Ramipril

Verfügbar ab:

Actavis Pty Ltd

Klasse:

Medicine Registered

Gebrauchsinformation

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RAMIPRIL-GA
_  _
_Ramipril _
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CONSUMER MEDICINE INFORMATION 
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WHAT IS IN THIS LEAFLET 

This leaflet answers some 
common questions about 
Ramipril-GA. 

It does not contain all the 
available information. 

It does not take the place of 
talking to your doctor or 
pharmacist. 

All medicines have risks and 
benefits. Your doctor has 
weighed the risks of you taking 
Ramipril-GA against the benefits 
they expect it will have for you. 

IF YOU HAVE ANY CONCERNS 
ABOUT TAKING THIS MEDICINE, 
ASK YOUR DOCTOR OR 
PHARMACIST. 

KEEP THIS LEAFLET WITH THE 
MEDICINE. You may need to 
read it again. 

WHAT RAMIPRIL-GA IS USED 
FOR 

Ramipril-GA belongs to a group 
of medicines called angiotensin 
converting enzyme (ACE) 
inhibitors. 

Ramipril-GA is used to treat: 
• high 
blood 
pressure 
(hypertension) 
•  heart failure after a heart 
attack 
•  kidney problems in some 
patients  
•  reduce the risk of 
cardiovascular problems 
and complications in 
patients aged over 55 years 
with heart or blood vessel 
disease, or diabetes. 

HYPERTENSION 

Ramipril-GA is used to lower 
high blood pressure 
(hypertension).  Everyone has 
blood pressure.  This pressure 
helps get your blood all around 
your body.  Your blood pressure 
may be different at different 
times of the day, depending on 
how busy or worried you are.  
You have hypertension (high 
blood pressure) when your 
blood pressure stays higher than 
is needed, even when you are 
calm and relaxed. 

There are usually no symptoms 
of hypertension.  The only way 
of knowing that you have 
hypertension is to have your 
blood pressure checked on a 
regular basis.  If high blood 
pressure is not treated it can 
lead to serious health problems, 
including stroke, heart disease 
and kidney failure. 

HEART FAILU

Fachinformation

Ramipril-GA PI v1 090810 
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RAMIPRIL-GA CAPSULES 
PRODUCT INFORMATION 

NAME OF THE MEDICINE 

Ramipril 

Ramipril's chemical name is
(2S,3aS,6aS)-1-[(S)-2-[[(S)-l-(ethoxycarbonyl)-3-phenylpropyl] 
amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid; its
structural formula is: 

Its empiric formula is C
23
H
32
N
2
O
5
, and its molecular weight is 416.5.  Ramipril has five chiral 
centres.  It has S-configuration in all five asymmetric carbon
atoms. 

CAS Number:  87333-19-5 

DESCRIPTION 

Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid
derivative.  It is a white, crystalline 
substance soluble in polar organic solvents and buffered aqueous
solutions.  Ramipril melts 
between 105°C and 112°C. 

PHARMACOLOGY  

MECHANISM OF ACTION 
Ramipril is a prodrug which, after absorption from the
gastrointestinal tract, is hydrolysed in the 
liver to form the active moiety, ramiprilat.  Ramipril
and ramiprilat inhibit angiotensin-converting 
enzyme (ACE) which is identical to KININASE II.  This converting
enzyme (ACE) is a peptidyl 
dipeptidase that  catalyses the conversion of angiotensin I to
the vasoconstrictor substance, 
angiotensin II.  Angiotensin II also stimulates aldosterone
secretion by the adrenal cortex, thus 
inhibition of ACE results in decreased plasma
angiotensin II, which leads to decreased 
vasopressor activity and to decreased aldosterone secretion.  The
latter decrease may result in 
a small increase in serum potassium. 

KININASE II is one of the enzymes responsible for the degradation
of bradykinin, a potent 
vasodepressor peptide.  The inhibition of KININASE II activity by
ramipril prevents the 
degradation of bradykinin thus leading to increased levels of this
potent vasodepressor 
substance.  While the mechanism through which ramipril lowers
blood pressure is believed to be 
primarily suppression of the renin-angiotensin-aldosterone system,
ramipri