PROCHLORAZINE TABLET

Land: Kanada

Sprache: Englisch

Quelle: Health Canada

Wirkstoff:

PROCHLORPERAZINE (PROCHLORPERAZINE MALEATE)

Verfügbar ab:

AA PHARMA INC

ATC-Code:

N05AB04

INN (Internationale Bezeichnung):

PROCHLORPERAZINE

Dosierung:

5MG

Darreichungsform:

TABLET

Zusammensetzung:

PROCHLORPERAZINE (PROCHLORPERAZINE MALEATE) 5MG

Verabreichungsweg:

ORAL

Einheiten im Paket:

100

Verschreibungstyp:

Prescription

Therapiebereich:

PHENOTHIAZINES

Produktbesonderheiten:

Active ingredient group (AIG) number: 0106181002; AHFS:

Berechtigungsstatus:

APPROVED

Berechtigungsdatum:

2000-02-03

Fachinformation

PRESCRIBING INFORMATION
PR
PROCHLORAZINE
PROCHLORPERAZINE MALEATE TABLETS USP
5 MG AND 10 MG PROCHLORPERAZINE/TABLET
ANTIPSYCHOTIC/ANTIEMETIC
AA PHARMA INC.
DATE OF REVISION:
1165 CREDITSTONE ROAD, UNIT #1
August 31, 2012
VAUGHAN, ONTARIO
L4K 4N7
CONTROL NUMBER: 158279
1
PRESCRIBING INFORMATION
PROCHLORAZINE
Prochlorperazine Tablets USP
5 mg and 10 mg
THERAPEUTIC CLASSIFICATION
Antipsychotic/Antiemetic
ACTIONS AND CLINICAL PHARMACOLOGY
Prochlorperazine is a piperazine phenothiazine derivative with
antipsychotic, antiemetic and weak sedative
activity.
Prochlorperazine has actions similar to those of other phenothiazine
derivatives but appears to be less
sedating and to have a weak propensity for causing hypotension or
potentiating the effects of CNS
depressants and anesthetics. However, it produces a high incidence of
extrapyramidal reactions.
Prochlorperazine is well absorbed from the gastrointestinal tract.
Onset of action following oral
administration is 30 to 40 minutes; 60 minutes for suppositories and
10 to 20 minutes after i.m.
administration. Duration of action for all routes is 3 to 4 hours.
Prochlorperazine distributes to most body
tissues with high concentrations being distributed into liver and
spleen. Prochlorperazine enters the
enterohepatic circulation and is excreted chiefly in the feces.
2
INDICATIONS AND CLINICAL USE
In the management of manifestations of psychotic disorders such as
agitation, confusion, delusion, tension
and anxiety.
It is also effective in controlling nausea and vomiting due to
stimulation of the chemoreceptor trigger zone.
In selected patients, prochlorperazine may be of value for the relief
of excessive anxiety, accompanied by
severe tension and agitation, associated with psychoneurotic or
somatic conditions.
CONTRAINDICATIONS
Should not be administered in the presence of circulatory collapse,
altered states of consciousness or
comatose states, particularly when these are due to intoxication with
central depressant drugs (alcohol,
hypnotics, narcotics). It is contraindicated