Lovir

Land: Australien

Sprache: Englisch

Quelle: Department of Health (Therapeutic Goods Administration)

Wirkstoff:

Aciclovir

Verfügbar ab:

Actavis Pty Ltd

Klasse:

Medicine Registered

Gebrauchsinformation

LOVIR
®
TABLETS 
CONSUMER MEDICINE INFORMATION 

WHAT IS IN THIS LEAFLET 

Please read this leaflet carefully before you take Lovir 
tablets. 
This leaflet answers some common questions about 
Lovir. It does not contain all available information, nor 
does it take the place of talking to you doctor or 
pharmacist. 
All medicines have risks and benefits. Your doctor 
has weighed the risks of you taking Lovir against the 
benefits this medicine is expected to have for you. 
You should ask your doctor or pharmacist if you have 
any questions about Lovir or if you have any trouble 
before, during or after taking Lovir. 
KEEP THIS LEAFLET WITH THE MEDICINE. You may need 
to read it again later. 
WHAT LOVIR IS USED FOR 

Lovir tablets contain aciclovir, a compound that 
belongs to a group of medicines called antivirals. 
Lovir tablets are for the treatment of shingles (herpes 
zoster), impaired immunity and/or genital herpes.  

In the case of shingles, Lovir works by stopping the 
multiplication of the virus which causes shingles. It 
can reduce the length and severity of an outbreak of 
shingles but it will not get rid of the virus from your 
body. 

Aciclovir at high strength is used as part of the 
management program for certain infections in people 
who also have the human immunodeficiency virus. It 
acts by preventing further damage to the immune 
system as a result of stopping production of herpes 
viruses. Aciclovir does not get rid of the virus from 
your body. 

Your doctor may have prescribed Lovir for another 
reason. If you are unsure why this medicine has been 
prescribed for you, speak to your doctor. 

This medicine is only available with a doctor’s 
prescription. 

BEFORE YOU TAKE LOVIR  
_ _
_WHEN YOU MUST NOT TAKE LOVIR_ 

DO NOT TAKE LOVIR IF YOU HAVE AN ALLERGY TO: 
•  Aciclovir or any of the ingredients listed at 
the end of this leafle

Fachinformation

PRODUCT INFORMATION 

NAME OF THE MEDICINE 

LOVIR TABLETS 

Active.  aciclovir 

CHEMICAL STRUCTURE: 

Chemical name: 9-((2-hydroxyethoxy) methyl) guanine 
Molecular formula: C
8
H
11
N
5
O
3

Molecular weight: 225.2 
CAS No: 59277-89-3 

DESCRIPTION 

Synthetic acyclic purine nucleoside analogue.  Chemical name:
9-((2-hydroxyethoxy) 
methyl) guanine.  It is a white crystalline powder. 

_Excipients_ – magnesium stearate, microcrystalline cellulose,
sodium starch glycollate, 
pregelatinised maize starch, colloidal anhydrous silica. 

PHARMACOLOGY 

ACTIONS – Antiviral agent. 

MICROBIOLOGY 

Aciclovir is an antiviral agent which is active in vitro
against _Herpes simples_ virus (HSV) 
types I and II and _Varicella zoster_ virus (VZV), the latter being
considerably less sensitive.  
The relationship between the level of in vitro sensitivity
of herpes viruses to aciclovir and 
clinical response to therapy has not been adequately established.
 Development of resistance 
by HSV to aciclovir has been documented.  Aciclovir needs to be
phosphorylated to the 
active compound, aciclovir triphosphate, in order to become active
against the virus.  Such 
conversion is very limited in normal cells and, in addition, cellular
DNA polymerase is not 
very sensitive to the active compound.  However in infected cells,
HSV or VZV coded 
thymidine kinase facilitates the conversion of aciclovir to aciclovir
monophosphate, which is 
then converted to aciclovir triphosphate by cellular enzymes.
 Aciclovir triphosphate acts as 
an inhibitor of and substrate for the herpes specified DNA
polymerase, preventing further 
viral DNA synthesis. 

2
PHARMACOKINETICS_ _

Aciclovir is only partially and variably absorbed from the gut.
 Estimated bioavailability 
following a dose of 200mg is about 20% and decreases to about half of
this with an 800mg 
dose.  Mean steady state peak and trough concentrations during dosage
of 200mg 
administered eve