LISINOPRIL tablet

Land: Vereinigte Staaten

Sprache: Englisch

Quelle: NLM (National Library of Medicine)

Wirkstoff:

LISINOPRIL (UNII: E7199S1YWR) (LISINOPRIL ANHYDROUS - UNII:7Q3P4BS2FD)

Verfügbar ab:

St Marys Medical Park Pharmacy

INN (Internationale Bezeichnung):

LISINOPRIL

Zusammensetzung:

LISINOPRIL 10 mg

Verschreibungstyp:

PRESCRIPTION DRUG

Berechtigungsstatus:

Abbreviated New Drug Application

Fachinformation

LISINOPRIL- LISINOPRIL TABLET
ST MARYS MEDICAL PARK PHARMACY
----------
LISINOPRIL TABLETS, USP
Rev. 12/09
RX ONLY
USE IN PREGNANCY
WHEN USED IN PREGNANCY, DURING THE SECOND AND THIRD TRIMESTERS, ACE
INHIBITORS CAN CAUSE
INJURY AND EVEN DEATH TO THE DEVELOPING FETUS. When pregnancy is
detected, Lisinopril Tablets
should be discontinued as soon as possible. See WARNINGS,
FETAL/NEONATAL MORBIDITY AND
MORTALITY.
DESCRIPTION
Lisinopril is an oral long-acting angiotensin converting enzyme
inhibitor. Lisinopril, a synthetic peptide
derivative, is chemically described as (S)-1-[ _N _
-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline
dihydrate. Its empirical formula is C
H
N
O
•2H
O and its structural formula is:
Lisinopril is a white to off-white, crystalline powder, with a
molecular weight of 441.53. It is soluble
in water and sparingly soluble in methanol and practically insoluble
in ethanol.
Lisinopril Tablets are supplied as 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg
and 40 mg tablets for oral
administration.
Inactive ingredients are as follows:
2.5 MG: Corn Starch, Colloidal Silicon Dioxide, Dibasic Calcium
Phosphate, Magnesium Stearate,
Mannitol, and Sodium Starch Glycolate.
5 MG, 10 MG, 20 MG AND 30 MG: Corn Starch, Colloidal Silicon Dioxide,
Dibasic Calcium Phosphate,
Magnesium Stearate, Mannitol, Red Iron Oxide, and Sodium Starch
Glycolate.
40 MG: Corn Starch, Colloidal Silicon Dioxide, Dibasic Calcium
Phosphate, Magnesium Stearate,
Mannitol, Sodium Starch Glycolate, and Yellow Iron Oxide.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION
Lisinopril inhibits angiotensin-converting enzyme (ACE) in human
subjects and animals. ACE is a
peptidyl dipeptidase that catalyzes the conversion of angiotensin I to
the vasoconstrictor substance,
angiotensin II. Angiotensin II also stimulates aldosterone secretion
by the adrenal cortex. The beneficial
effects of lisinopril in hypertension and heart failure appear to
result primarily from suppression of the
renin-angiotensin-aldosterone system. Inhibition of ACE results in
decreased plasma ang