Land: Australien
Sprache: Englisch
Quelle: Department of Health (Therapeutic Goods Administration)
Mefloquine hydrochloride
Roche Products Pty Ltd
Medicine Registered
LARIAM ® _contains the active ingredient mefloquine_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about LARIAM tablets. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking LARIAM tablets against the benefits expected for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT LARIAM IS USED FOR LARIAM is used to prevent and treat malaria. LARIAM contains the active ingredient mefloquine. LARIAM belongs to a group of medicines called quinolones (pronounced kwin- o-lones). LARIAM works by killing the parasites that may cause or have caused malaria. _WHERE AND HOW YOU CAN_ _CONTRACT MALARIA_ Malaria is an infectious disease that is widespread in tropical and subtropical areas of Africa, Latin America, Asia and countries around the Pacific. There are different forms of malaria, each of them caused by a specific parasite transmitted to humans by the bite of the Anopheles mosquito. _PRECAUTIONS AGAINST MALARIA_ The best protection against malaria is to avoid mosquito bites. The mosquito that causes malaria mainly bites between dusk and dawn. Therefore the following precautionary measures are recommended: • during this period, wear light- coloured clothing that covers as much of your skin as possible • apply mosquito repellent to your uncovered skin and to your clothes • when sleeping in rooms that are not protected against mosquitoes, use an effective mosquito net well tucked under the mattress • additional protection is provided by smoke spirals, insect sprays and candles. _SYMPTOMS OF MALARIA_ The symptoms of malaria may often be mild. However, malaria should be suspected if, after one week in a malarial area, you suffer unexplained fever with or without other symptoms such as headache, Lesen Sie das vollständige Dokument
Lariam PI 130802 _ _ _ _ 1 of 14 CDS 4.0 1 . NAME OF THE MEDICINE LARIAM ® MEFLOQUINE HYDROCHLORIDE Chemical name: _dl-erythro-alpha-2-piperidy-2,8-bis(trifluoromethyl)-4-quinoline methanol _ OH N N H H H CF CF 3 3 MW: 414.78 CAS registry number: 51773-92-3 DESCRIPTION Mefloquine is an odourless, bitter-tasting, white crystalline powder. It is soluble in methanol and ethanol but practically insoluble in water. A 1% aqueous suspension has a pH of 5.6. LARIAM tablets are cylindrical biplanar, white to off-white, cross-scored with break bars on both faces and marked with "RO", "C", "HE" and an imprinted hexagon in the quadrants of one face. They contain 250 mg mefloquine in the form of mefloquine hydrochloride (274.09 mg). LARIAM tablets also contain the following excipients: poloxamer 3800, microcrystalline cellulose, lactose, maize starch, crospovidone, ammonium calcium alginate, talc and magnesium stearate. LARIAM (mefloquine) is an antimalarial belonging to the quinoline-methanol group of medicines and is structurally related to quinine. PHARMACOLOGY _PHARMACODYNAMICS _ The effectiveness in the treatment of malaria is due essentially to destruction of the asexual intraerythrocytic forms of the human malarial parasites: _Plasmodium falciparum, P. vivax, P. _ _malariae and P. ovale_. However data concerning the treatment of _P.malariae_ and _P.ovale_ were limited. It is also effective against _P. falciparum_ infections resistant to other antimalarials such as chloroquine and other 4-amino-quinoline derivatives, proguanil, pyrimethamine and pyrimethamine-sulfonamide combinations. Laboratory animal studies have shown that resistance to mefloquine can be readily induced in the malarial Lesen Sie das vollständige Dokument