GUARDIAN FEVER AND PAIN RELIEF TABLET 500MG

Land: Malaysia

Sprache: Englisch

Quelle: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Wirkstoff:

Paracetamol

Verfügbar ab:

GUARDIAN HEALTH AND BEAUTY SDN. BHD.

INN (Internationale Bezeichnung):

Paracetamol

Einheiten im Paket:

30 Tablets; 100 Tablets; 10 Tablets; 4 Tablets; 80 Tablets

Hergestellt von:

PT Medifarma Laboratories

Fachinformation

GDN Fever & Pain Relief MYS Insert
Opsi 2
70 (W) x 192 (H) mm
PRODUC
PHARMACODYNAMICS
NAME AND STRENGTH OF ACTIVE PHARMACEUTICAL INGREDIENT(S)
T DESCRIPTION
Paracetamol ................................................ 500 mg
Analgesic
The mechanism of analgesic action has not been fully determined.
Paracetamol may act
predominantly by inhibiting prostaglandin synthesis in the central
nervous system
(specifically cyclooxygenase (COX)-2) and, to a lesser extent, through
a peripheral
action by blocking pain impulse generation.
The peripheral action may also be due to inhibition of prostaglandin
synthesis or to
inhibition of the synthesis or actions of other substances that
sensitize pain receptors
to mechanical or chemical stimulation.
Antipyretic
Paracetamol act centrally on the hypothalamic heat-regulating center
to produce
peripheral vasodilatation resulting in increase blood flow through the
skin, sweating
and heat loss. Paracetamol reduces fever by inhibiting the formulation
and release of
prostaglandins in the CNS and by inhibiting endogenous pyrogens at the
hypothalamic
thermoregulator center.
PHARMACOKINETICS
Following oral administration paracetamol is rapidly absorbed.
Paracetamol absorption takes place mainly in the small intestine and
therefore the rate
of absorption is depending on the rate of gastric emptying. It has
been shown that
drugs which delay gastric emptying also delay the absorption of
paracetamol whereas
metoclopramide (a drug which increases the rate of gastric emptying)
accelerates
absorption of the analgesic through the total amount absorbed doses
not increase.
The presence of food in the stomach has also been reported to reduce
the rate of
absorption of paracetamol. Alterations in gastric pH have no
appreciable effect on
paracetamol absorption. During absorption, the amount of paracetamol
which is
inactivated is negligible and it has been shown that paracetamol does
not affect gastric
mucosal permeability and does not produce mucosal bleeding.
Peak plasma concentrations are reached 1 hou