EPINEPHRINE injection solution

Land: Vereinigte Staaten

Sprache: Englisch

Quelle: NLM (National Library of Medicine)

Wirkstoff:

Epinephrine (UNII: YKH834O4BH) (Epinephrine - UNII:YKH834O4BH)

Verfügbar ab:

General Injectables & Vaccines, Inc

INN (Internationale Bezeichnung):

Epinephrine

Zusammensetzung:

Epinephrine 1 mg in 1 mL

Verschreibungstyp:

PRESCRIPTION DRUG

Berechtigungsstatus:

New Drug Application

Fachinformation

EPINEPHRINE- EPINEPHRINE INJECTION, SOLUTION
GENERAL INJECTABLES & VACCINES, INC
----------
EPINEPHRINE 1 MG/ML INJECTION, USP 1 ML 5 PK SINGLE DOSE AMPULE
DES CRIPTION
AMPUL
PROTECT FROM LIGHT UNTIL READY TO USE.
RX ONLY
Epinephrine Injection, USP 1:1000 is a sterile, nonpyrogenic solution.
Each mL contains epinephrine 1
mg; sodium chloride 9 mg; sodium metabisulfite 0.9 mg added. May
contain hydrochloric acid for pH
adjustment.
The solution contains no bacteriostat or antimicrobial agent. It is
administered by the following routes:
intravenous, intracardiac (left ventricular chamber), via endotracheal
tube into the bronchial tree,
subcutaneous or intramuscular.
Epinephrine, USP is a sympathomimetic (adrenergic) agent designated
chemically as 4-[1-hydroxy-2
(methylamino) ethyl]-1,2 benzenediol, a white, microcrystalline
powder. It has the following structural
formula:
Sodium Chloride, USP is chemically designated NaCl, a white,
crystalline compound freely soluble in
water.
CLINICAL PHARMACOLOGY
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. To a variable
degree it acts on both alpha and beta receptor sites of sympathetic
effector cells. Its most prominent
actions are on the beta receptors of the heart, vascular and other
smooth muscle. When given by rapid
intravenous injection, it produces a rapid rise in blood pressure,
mainly systolic, by (1) direct
stimulation of cardiac muscle which increases the strength of
ventricular contraction, (2) increasing the
heart rate and (3) constriction of the arterioles in the skin, mucosa
and splanchnic areas of the
circulation.
When given by slow intravenous injection epinephrine usually produces
only a moderate rise in systolic
and a fall in diastolic pressure. Although some increase in pulse
pressure occurs, there is usually no
great elevation in mean blood pressure. Accordingly, the compensatory
reflex mechanisms that come
into play with a pronounced increase in blood pressure do not
antagonize the direct cardiac actions of
epinephrine