Co-Amoxiclav for Injection 1.2g

Land: Malaysia

Sprache: Englisch

Quelle: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Wirkstoff:

POTASSIUM CLAVULANATE; Amoxicillin Sodium

Verfügbar ab:

AVERROES PHARMACEUTICALS SDN. BHD.

INN (Internationale Bezeichnung):

POTASSIUM CLAVULANATE; Amoxicillin Sodium

Einheiten im Paket:

0010Units Units; 0 0 1 Units Units; 10 Units Units

Hergestellt von:

KARNATAKA ANTIBIOTICS & PHARMACEUTICALS LIMITED

Fachinformation

CO-AMOXICLAV FOR INJECTION 1.2 G
AMOXICILLIN 1000 MG
CLAVULANIC ACID 200 MG
PRODUCT NAME
Co-Amoxiclav for Injection 1.2 g
PRODUCT DESCRIPTION
Almost white-colored powder for injection.
COMPOSITION
Each vial contains:
Amoxicillin sodium equivalent to Amoxicillin 1000 mg
Potassium clavulanate equivalent to Clavulanic Acid 200 mg
PHARMACODYNAMICS
Amoxicillin is an orally active member of the penicillin family. In
amoxicillin, the benzyl
ring in site change extends the range of antimicrobial activity into
the gram-negative
bacteria. It is bactericidal for both gram-positive and negative
bacteria.
Clavulanate is a ß-lactam antibiotic and interacts with ß-lactamase,
this interaction may
lead to enzyme induction, inactivation of the enzyme, and hydrolysis
of the ß-lactam ring
is used clinically only in combination with amoxicillin.
Amoxicillin kills bacteria by interfering with the synthesis of the
bacteria cell wall. As the
lactamase enzyme secreted by the bacteria destroys amoxicillin the
drug is ineffective in
most staphylococcal infections. An increasing percentage of
_Salmonella_
spp.,
_E. coli, Proteus mirabilis_
,
_Shigella_
spp. are not sensitive to amoxicillin. The spectrum of
activity of amoxicillin may be extended by the concomitant use of
ß-lactamase inhibitors
such as clavulanic acid. Clavulanic acid has been reported to enhance
the activity of
amoxicillin, against several species not generally considered
sensitive. Clavulanate by
itself has little antibacterial activity. However, in association with
amoxicillin, it produces
an antibiotic agent of broad-spectrum.
Co-Amoxiclav is bactericidal to a wide range of organisms such as:
Gram-positive:
Aerobes:
*
_Enterococcus _
_faecalis_
,
_Streptococcus _
_pneumoniae_
,
_Streptococcus pyogenes_
,
_Streptococcus viridans_
, *
_Staphylococcus aureus_
, *Coagulase-
negative staphylococci (including
_Staphylococcus epidermidis_
),
_Corynebacterium _
sp,
*
_Bacillus _
_anthracis, _
_Listeria _
_monocytogenes, _
_Enterococcus _
_faecium, _
_Streptococcus _
_agalact