Canidryl Tablet 20mg For Dogs Flavoured

Land: Malaysia

Sprache: Englisch

Quelle: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Wirkstoff:

CARPROFEN

Verfügbar ab:

Rhone Ma Malaysia Sdn Bhd

INN (Internationale Bezeichnung):

CARPROFEN

Einheiten im Paket:

100tablet Tablets

Hergestellt von:

Chanelle Pharmaceuticals Manufacturing Limited

Fachinformation

VERSION: 5
MMM/YY: XXX
GMP
COMPOSITION:
ONE GRILLED MEAT FLAVOURED TABLET CONTAINS:
ACTIVE INGREDIENT
Carprofen 20.0 mg/tablet, Carprofen 50.0 mg/tablet, Carprofen 100.0
mg/tablet.
PRODUCT DESCRIPTION: Canidryl 20mg & 50mg : A plain round flat
bevelled edge tablet,
white to off-white flavoured tablet with a breakline on one side.
Canidryl 100mg : A white to off-white round shape flavoured tablet
with a cross break line
on one side. The tablets can be divided into equal halves or quaters.
PHARMACODYNAMICS:
Carprofen
is
a
member
of
the
2-arylpropionic
acid
group
of
non-steroidal
anti-inflammatory
drugs
(NSAIDs),
and
possesses
anti-inflammatory,
analgesic and antipyretic activity. Carprofen is a chiral drug with
the S(+) enantiomer being
more active than the R(-) enantiomer. Carprofen, like most other
NSAIDs is an inhibitor of
the enzyme cyclo-oxygenase of the arachidonic acid cascade. However,
the inhibition of
prostaglandin synthesis by carprofen is slight in relation to its
anti-inflammatory and
analgesic potency. The precise mode of action of carprofen is not
clear.
PHARMACOKINETICS: After oral administration, carprofen is well
absorbed in the dogs.
Following
the
administration
of
Canidryl
tablets
in
dogs,
a
mean
Cmax
(maximum
concentration in serum) of 15.8 µg/ml and 12.2 µg/ml was achieved at
approximately 2
hours
and
1.7
hours
for
Carprofen
R(-)
and
Carprofen
S(+),
respectively.
For
both
enantiomers, the mean half-life was approximately 6 hours. The
analgesic effect from each
dose persists for at least 12 hours.
Carprofen has a small volume of distribution and a low systemic
clearance. It is highly
bound to plasma protein.
Carprofen is metabolised in the liver by conjugation and oxidation.
The excretion of the
glycuronide conjugate is mainly faecal after biliary excretion.
INDICATION: _ In the dog:_ Reduction of inflammation and pain caused
by musculo-skeletal
disorders and degenerative joint disease. As a follow up to parenteral
analgesia in the
management of post-operative pain following soft tissue surge