AMIODARONE HYDROCHLORIDE tablet

Land: Vereinigte Staaten

Sprache: Englisch

Quelle: NLM (National Library of Medicine)

Wirkstoff:

Amiodarone Hydrochloride (UNII: 976728SY6Z) (Amiodarone - UNII:N3RQ532IUT)

Verfügbar ab:

Avera McKennan Hospital

INN (Internationale Bezeichnung):

Amiodarone Hydrochloride

Zusammensetzung:

Amiodarone Hydrochloride 200 mg

Verschreibungstyp:

PRESCRIPTION DRUG

Berechtigungsstatus:

Abbreviated New Drug Application

Fachinformation

AMIODARONE HYDROCHLORIDE- AMIODARONE HYDROCHLORIDE TABLET
AVERA MCKENNAN HOSPITAL
----------
AMIODARONE HCL
TABLETS
RX ONLY
DESCRIPTION
Amiodarone HCl is a member of a class of antiarrhythmic drugs with
predominantly Class III (Vaughan
Williams' classification) effects, available for oral administration
as white tablets containing 100 mg of
amiodarone hydrochloride, light orange, scored tablets containing 200
mg of amiodarone
hydrochloride, peach, scored tablets containing 300 mg of amiodarone
hydrochloride, and light yellow,
scored tablets containing 400 mg of amiodarone hydrochloride. The
inactive ingredients present are
colloidal silicon dioxide, corn starch, D&C yellow No. 10 lake (200
and 400 mg only), FD&C yellow
No. 6 lake (200 and 300 mg only), lactose anhydrous, magnesium
stearate and povidone. Amiodarone is
a benzofuran derivative: 2-butyl-3- benzofuranyl
4-[2-(diethylamino)-ethoxy]-3,5-diiodophenyl ketone
hydrochloride.
The structural formula is as follows:
C
H I
NO ·HCL MOLECULAR WEIG HT: 681.8
Amiodarone HCl is a white to cream-colored crystalline powder. It is
slightly soluble in water, soluble
in alcohol, and freely soluble in chloroform. It contains 37.3% iodine
by weight.
CLINICAL PHARMACOLOGY
ELECTROPHYSIOLOGY/MECHANISMS OF ACTION
In animals, amiodarone HCl is effective in the prevention or
suppression of experimentally induced
arrhythmias. The antiarrhythmic effect of amiodarone may be due to at
least two major properties:
1. a prolongation of the myocardial cell-action potential duration and
refractory period and
2. non-competitive antagonism of α- and β-adrenoceptors.
Amiodarone prolongs the duration of the action potential of all
cardiac fibers while causing minimal
reduction of dV/dt (maximal upstroke velocity of the action
potential). The refractory period is
prolonged in all cardiac tissues. Amiodarone increases the cardiac
refractory period without
influencing resting membrane potential, except in automatic cells
where the slope of the prepotential is
reduced, generally reducing autom