TRIAMTERENE AND HYDROCHLOROTHIAZIDE tablet

Land: USA

Sprog: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv bestanddel:

TRIAMTERENE (UNII: WS821Z52LQ) (TRIAMTERENE - UNII:WS821Z52LQ), HYDROCHLOROTHIAZIDE (UNII: 0J48LPH2TH) (HYDROCHLOROTHIAZIDE - UNII:0J48LPH2TH)

Tilgængelig fra:

Bryant Ranch Prepack

Indgivelsesvej:

ORAL

Recept type:

PRESCRIPTION DRUG

Terapeutiske indikationer:

This fixed combination drug is not indicated for the initial therapy of edema or hypertension except in individuals in whom the development of hypokalemia cannot be risked. - Triamterene and hydrochlorothiazide tablets are indicated for the treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone. - Triamterene and hydrochlorothiazide tablets are also indicated for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot be risked (e.g., patients on concomitant digitalis preparations, or with a history of cardiac arrhythmias, etc.). Triamterene and hydrochlorothiazide tablets may be used alone or in combination with other antihypertensive drugs, such as beta-blockers. Since triamterene and hydrochlorothiazide may enhance the actions of these drugs, dosage adjustments may be necessary. The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not

Produkt oversigt:

NDC: 63629-8191-1: 30 Tablets in a BOTTLE

Autorisation status:

Abbreviated New Drug Application

Produktets egenskaber

TRIAMTERENE AND HYDROCHLOROTHIAZIDE- TRIAMTERENE AND
HYDROCHLOROTHIAZIDE TABLET
BRYANT RANCH PREPACK
----------
TRIAMTERENE AND HYDROCHLOROTHIAZIDE TABLETS, USP
REVISED: NOVEMBER 2020
RX ONLY
DESCRIPTION:
Triamterene and hydrochlorothiazide tablets, USP combine triamterene
USP, a
potassium-conserving diuretic, with the natriuretic agent,
hydrochlorothiazide, USP.
Triamterene and hydrochlorothiazide tablets, USP are available in two
strengths. Each
triamterene and hydrochlorothiazide tablet USP, 75 mg/50 mg, contains
triamterene
USP, 75 mg and hydrochlorothiazide USP, 50 mg. Each triamterene and
hydrochlorothiazide tablet USP,
37.5 mg/25 mg, contains triamterene USP, 37.5 mg and
hydrochlorothiazide USP, 25
mg.
Both strengths of triamterene and hydrochlorothiazide tablets, USP for
oral
administration contain the following inactive ingredients: anhydrous
lactose, magnesium
stearate, microcrystalline cellulose, polacrilin potassium,
polyethylene glycol 8000, and
povidone. Triamterene and hydrochlorothiazide tablets, 37.5 mg/25 mg
also contain
FD&C Blue No. 2 Aluminum Lake.
Triamterene, USP is 2,4,7-triamino-6-phenylpteridine. Triamterene, USP
is practically
insoluble in water, benzene, chloroform, ether and dilute alkali
hydroxides. It is soluble in
formic acid and sparingly soluble in methoxyethanol. Triamterene, USP
is very slightly
soluble in acetic acid, alcohol and dilute mineral acids. Its
molecular weight is 253.27. Its
structural formula is:
C
H N
TRIAMTERENE, USP
Hydrochlorothiazide, USP is
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-
sulfonamide 1,1-dioxide. Hydrochlorothiazide, USP is slightly soluble
in water and freely
soluble in sodium hydroxide solution, n-butylamine and
dimethylformamide. It is
sparingly soluble in methanol and insoluble in ether, chloroform and
dilute mineral acids.
12
11
7
Its molecular weight is 297.73. Its structural formula is:
C H CLN O S
HYDROCHLOROTHIAZIDE, USP
CLINICAL PHARMACOLOGY:
Triamterene and hydrochlorothiazide is a diuretic, antihypertensive
drug product,
princ