Land: New Zealand
Sprog: engelsk
Kilde: Medsafe (Medicines Safety Authority)
Hetastarch 6%{relative}
Biomed Limited
Poly-O-(2-hydroxyethyl)-starch 6% w/v
6 %
Solution for injection
Active: Hetastarch 6%{relative} Excipient: Sodium chloride Sodium hydroxide Water for injection
Bag, plastic, Flexible sealed pack, 500 mL
General sale
General sale
Serumwerk Bernburg AG
Package - Contents - Shelf Life: Bag, plastic, Flexible sealed pack - 500 mL - 36 months from date of manufacture stored at or below 25°C. Store at 15 - 25°C. 24 hours opened stored at or below 25°C. Store at 15 - 25°C.
2002-09-16
DATA SHEET S TAR Q UIN ® 200 10% PRESENTATION S TAR Q UIN 200 is a sterile injection containing 10% pentastarch in 0.9% sodium chloride injection. It is a clear, pale yellow to amber solution. Each 100 mL of solution contains: Pentastarch 10 g Sodium Chloride BP 0.9 g Water for Injection BP q.s to 100 ml pH adjusted with Sodium Hydroxide BP Concentration of Electrolytes: Sodium 150 mmol Chloride 150 mmol pH approximately 5.0 (3-5-7.0) Calculated osmolarity 310 mOsmol/litre USES _ACTIONS _ Pentastarch is a colloid synthesized from a waxy starch composed almost entirely of amylopectin. Hydroxyethyl ether groups are added to the glucose units of the starch and the resultant material is hydrolyzed to yield a product with a molecular weight suitable for use as a plasma volume expander and erythrocyte sedimenting agent. Pentastarch is characterized by its molar substitution and by its molecular weight. The molar substitution is 0.5 which means pentastarch has 50 hydroxyethyl groups for every 100 glucose units. The average molecular weight is approximately 200,000 with 90% of the polymers falling between the range of 15,000 and 600,000. Hydroxyethyl groups are attached by ether linkages at the C 2 and C 6 positions on the glucose molecule. The C 2 /C 6 ratio is within the range 5.0 – 7.0/1. Intravenous infusion of S TAR Q UIN 200 10% injection results in a plasma expansion approximately 1.5 times greater than the infused volume due to influx of interstitial fluid in the intravasal space. The plasma volume expansion resulting from intravenous infusion of S TAR Q UIN 200 10% injection persists for approximately 12 hours. The degree of plasma volume expansion and improveme Læs hele dokumentet